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Current Perspectives On Emerging Biomarkers For Rheumatoid Arthritis-Associated Interstitial Lung Disease

Authors Amigues I, Ramadurai D, Swigris JJ

Received 27 February 2019

Accepted for publication 24 September 2019

Published 15 October 2019 Volume 2019:11 Pages 229—235

DOI https://doi.org/10.2147/OARRR.S166070

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Professor Chuan-Ju Liu


Isabelle Amigues,1 Deepa Ramadurai,2 Jeffrey J Swigris3

1Division of Rheumatology, National Jewish Health, Denver, CO, USA; 2Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; 3Division of Pulmonary, Critical Care and Sleep Medicine, Interstitial Lung Disease Program, National Jewish Health, Denver, CO, USA

Correspondence: Jeffrey J Swigris
National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA
Email swigrisj@njc.org

Abstract: Rheumatoid arthritis (RA) is a common systemic autoimmune disease whose fibro-inflammatory manifestations may affect a number of tissues and organs, including the lungs. In fact, interstitial lung disease (ILD) is a leading cause of mortality among patients with RA. RA-related interstitial lung disease (RA-ILD) most often presents in an injury pattern called usual interstitial pneumonia (UIP), which portends a relatively worse prognosis than other less commonly occurring patterns of RA-ILD, like non-specific interstitial pneumonia (NSIP). Biomarkers from serum or bronchoalveolar lavage fluid could aid in the identification of patients at risk for RA-ILD, the detection of patients most likely to develop the UIP pattern of RA-ILD, and the prediction of disease behaviour over time. Notably, the use of highly sensitive serologic biomarkers, including rheumatoid factor (RF) and antibodies targeting cyclic citrullinated peptides, while somewhat specific for RA joint disease, have only limited utility as biomarkers for RA-ILD. Candidate biomarkers for RA-ILD include these and other autoantibodies as well as certain genes and molecules that hold promise as biomarkers in other forms of ILD. In this manuscript, we summarize the state of knowledge on biomarkers for the development and progression of RA-ILD.

Keywords: rheumatoid arthritis, interstitial lung disease, pulmonary fibrosis, usual interstitial pneumonia, biomarker, antibody

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