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Critical appraisal of pemetrexed in the treatment of NSCLC and metastatic pulmonary nodules

Authors Li X, Wei S, Chen J

Received 29 November 2013

Accepted for publication 17 February 2014

Published 6 June 2014 Volume 2014:7 Pages 937—945

DOI https://doi.org/10.2147/OTT.S45148

Checked for plagiarism Yes

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Xin Li, Sen Wei, Jun Chen

Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, Heping District, Tianjin, People's Republic of China

Abstract: Pemetrexed, a new multitarget antifolate antineoplastic agent, has significantly improved the overall survival in nonsquamous non-small-cell lung cancer patients. Presently, pemetrexed is recommended for first line treatment in combination with platinum derivatives, for second line treatment as a single agent and, more recently, as maintenance treatment after first line chemotherapy. In this article we critically appraise the status of pemetrexed including pharmacodynamics, pharmacokinetics, toxicity, and the cost effectiveness of pemetrexed, as well as the predictive biomarkers for pemetrexed based chemotherapy.

Keywords: chemotherapy, non-small-cell lung cancer, pemetrexed

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