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Correlation of selected stress associated factors with vitamin D deficiency in Jordanian men and women

Authors Abu-Samak MS, AbuRuz ME, Masa'Deh R, Khuzai R, Jarrah S

Received 14 December 2018

Accepted for publication 20 March 2019

Published 28 June 2019 Volume 2019:12 Pages 225—233

DOI https://doi.org/10.2147/IJGM.S198175

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Cristina Weinberg

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser


Mahmoud S Abu-Samak,1 Mohannad Eid AbuRuz,2 Rami Masa’Deh,2 Rula Khuzai,2 Samiha Jarrah2

1Department of Clinical Pharmacy and Therapeutics, Applied Science Private University, Amman, Jordan; 2Department of Clinical Nursing, School of Nursing, Applied Science Private University, Amman, Jordan

Background: To identify stress associated factors for vitamin D deficiency (VDD) in healthy Jordanian people based on serum 25(OH)D levels.
Design: Prospective cohort study.
Methods: Three hundred and seventy-one Jordanian men and women aged 17–52 years, who were identified as VD deficient 25(OH)D <30 ng/mL, were eligible to participate in the study. Serum vitamin 25(OH) D was measured using chemiluminescent immunoassay. Cortisol, parathyroid hormone, calcium, phosphate, fasting lipid profile, and blood glucose were also analyzed. Questionnaires were used to collect lifestyles parameters. Anthropometric parameters including: body mass index (BMI), waist (W) and hip (H) circumferences, W/H ratio (WHR) were also calculated.
Results: The vast majority (91%) of the participants had vitamin D deficiency (25- (OH) D <30 ng/mL). Positive correlations were observed between vitamin D deficiency and the following anthropometric parameters in all study sample; gender (P=0.010), height (P=0.22), height/hip ratio (P=0.015) and waist/hip ratio (P=0.013). Lifestyle parameters that indicated very weak positive correlations with VDD were number of family members (P=0.011) and insufficient exposure to sunlight (P=0.023). The following clinical parameters showed weak or very weak correlations with VDD; serum cortisol (r=0.318), low density lipoprotein (r=0.246) and total cholesterol (r=0.133). Skin color and water pipe tobacco smoking were added to the multivariable stepwise regression analyses as they have been weakly correlated with VDD. These predictors together explained only 12.2% of the variance in serum cortisol levels in the VDD study sample.
Conclusion: A weak positive association between VDD and elevated serum cortisol was observed in this study. Subcutaneous changes may be involved in that association but further studies are needed to clarify a potential role for adrenocorticotropic hormone (ACTH).

Keywords: Vitamin D deficiency, stress, cortisol, smoking, obesity


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