Back to Journals » OncoTargets and Therapy » Volume 12

Contribution of interaction between genetic variants of interleukin-11 and Helicobacter pylori infection to the susceptibility of gastric cancer

Authors Liao C, Hu S, Zheng Z, Tong H

Received 2 May 2019

Accepted for publication 24 July 2019

Published 11 September 2019 Volume 2019:12 Pages 7459—7466

DOI https://doi.org/10.2147/OTT.S214238

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Ms Rachel Predeepa

Peer reviewer comments 2

Editor who approved publication: Dr Sanjeev Srivastava


Chuanwen Liao,1 Shuqin Hu,2 Zihan Zheng,1 Huazhang Tong3

1Department of Gastrointestinal Surgery, People’s Hospital of Jiangxi Province, Nanchang, Jiangxi Province 330006, People’s Republic of China; 2Medical Department, People’s Hospital of Jiangxi Province, Nanchang, Jiangxi Province 330006, People’s Republic of China; 3Department of Radiotherapy, People’s Hospital of Jiangxi Province, Nanchang, Jiangxi Province 330006, People’s Republic of China

Correspondence: Huazhang Tong
Department of Radiotherapy, People’s Hospital of Jiangxi Province, No 92, Aiguo Road, Nanchang, Jiangxi Province 330006, People’s Republic of China
Tel +86 7 918 689 5513
Fax +86 7 918 689 5513
Email tong_huazhang@sina.cn

Background: Gastric cancer (GC) ranks the second leading cause of cancer-related mortality worldwide. We aimed to clarify the relevance of genetic variants of IL-11, a hub of various carcinogenic pathways, as well as their interactions with Helicobacter pylori (H. pylori) infection in the development of GC.
Methods: A case–control study with 880 GC cases and 900 healthy controls was conducted in a Chinese population. Six tagSNPs were detected by Taqman Allelic Discrimination assay, while H. pylori status was detected by Typing Detection Kit for Antibody to H. pylori and serum IL-11 level was measured using ELISA method.
Results: We found that rs1126760 (C vs T: OR=1.39, 95% CIs=1.13–1.70, P=0.002) and rs1126757 (C vs T: OR=0.82, 95% CIs=0.72–0.93, P=0.002) were significantly associated with susceptibility of GC. Even adjusted for Bonferroni correction, the results were still significant (P=0.002×6=0.012). IL-11 rs1126760 was significantly associated with higher serum and expression level of IL-11, while rs1126757 was significantly associated with lower serum IL-11 level (P<0.001). Significant interaction with H. pylori infection was identified for rs1126760 (P for interaction =0.005). Higher expression of the IL-11 gene was significant with development and poor prognosis of GC.
Conclusion: Our study provides strong evidence that genetic variants of the IL-11 gene may interact with H. pylori infection and contribute to the development of GC. Further studies with larger sample size and functional experiments are needed to validate our findings.

Keywords: gastric cancer, polymorphism, IL-11, Helicobacter pylori

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]