Contribution of interaction between genetic variants of interleukin-11 and Helicobacter pylori infection to the susceptibility of gastric cancer
Authors Liao C, Hu S, Zheng Z, Tong H
Received 2 May 2019
Accepted for publication 24 July 2019
Published 11 September 2019 Volume 2019:12 Pages 7459—7466
Checked for plagiarism Yes
Review by Single-blind
Peer reviewer comments 2
Editor who approved publication: Dr Sanjeev Srivastava
Chuanwen Liao,1 Shuqin Hu,2 Zihan Zheng,1 Huazhang Tong3
1Department of Gastrointestinal Surgery, People’s Hospital of Jiangxi Province, Nanchang, Jiangxi Province 330006, People’s Republic of China; 2Medical Department, People’s Hospital of Jiangxi Province, Nanchang, Jiangxi Province 330006, People’s Republic of China; 3Department of Radiotherapy, People’s Hospital of Jiangxi Province, Nanchang, Jiangxi Province 330006, People’s Republic of China
Correspondence: Huazhang Tong
Department of Radiotherapy, People’s Hospital of Jiangxi Province, No 92, Aiguo Road, Nanchang, Jiangxi Province 330006, People’s Republic of China
Tel +86 7 918 689 5513
Fax +86 7 918 689 5513
Background: Gastric cancer (GC) ranks the second leading cause of cancer-related mortality worldwide. We aimed to clarify the relevance of genetic variants of IL-11, a hub of various carcinogenic pathways, as well as their interactions with Helicobacter pylori (H. pylori) infection in the development of GC.
Methods: A case–control study with 880 GC cases and 900 healthy controls was conducted in a Chinese population. Six tagSNPs were detected by Taqman Allelic Discrimination assay, while H. pylori status was detected by Typing Detection Kit for Antibody to H. pylori and serum IL-11 level was measured using ELISA method.
Results: We found that rs1126760 (C vs T: OR=1.39, 95% CIs=1.13–1.70, P=0.002) and rs1126757 (C vs T: OR=0.82, 95% CIs=0.72–0.93, P=0.002) were significantly associated with susceptibility of GC. Even adjusted for Bonferroni correction, the results were still significant (P=0.002×6=0.012). IL-11 rs1126760 was significantly associated with higher serum and expression level of IL-11, while rs1126757 was significantly associated with lower serum IL-11 level (P<0.001). Significant interaction with H. pylori infection was identified for rs1126760 (P for interaction =0.005). Higher expression of the IL-11 gene was significant with development and poor prognosis of GC.
Conclusion: Our study provides strong evidence that genetic variants of the IL-11 gene may interact with H. pylori infection and contribute to the development of GC. Further studies with larger sample size and functional experiments are needed to validate our findings.
Keywords: gastric cancer, polymorphism, IL-11, Helicobacter pylori
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