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Contribution of dysregulated circRNA_100876 to proliferation and metastasis of esophageal squamous cell carcinoma
Authors Cao S, Chen G, Yan L, Li L, Huang X
Received 18 June 2018
Accepted for publication 14 August 2018
Published 24 October 2018 Volume 2018:11 Pages 7385—7394
DOI https://doi.org/10.2147/OTT.S177524
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Cristina Weinberg
Peer reviewer comments 2
Editor who approved publication: Dr Federico Perche
Sai Cao,1,* Guohao Chen,2,* Liumei Yan,3,* Libo Li,2 Xianying Huang4
1Department of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangdong 510515, China; 2Department of General Surgery, Dongguan People’s Hospital, Dongguan 523000, China; 3Department of Gastroenterology, Wuzhou Red Cross Hospital, Wuzhou 543000, China; 4Department of Vascular Surgery, Nanfang Hospital, Southern Medical University, Guangdong 510515, China
*These authors contributed equally to this work
Purpose: Accumulating evidence demonstrates that circRNAs regulate diverse cellular processes and cancer progression. However, it remains unclear whether circRNAs play any functional role in esophageal squamous cell carcinoma (ESCC).
Materials and methods: The significance of circRNA_100876 in ESCC was analyzed by studying circRNA_100876 expression in ESCC tissues and the association between circRNA_100876 expression and clinicopathologic parameters. The biological effects of circRNA_100876 knockdown by lentivirus-mediated siRNAs on cell proliferation, cell cycle, apoptosis, and migration were investigated in vitro and in vivo.
Results: CircRNA_100876 expression was upregulated (P<0.05) and was negatively correlated with survival outcome (P<0.05) in ESCC. Inhibition of proliferation, migration, invasion, and epithelial–mesenchymal transition progression was confirmed after circRNA_100876 depletion.
Conclusion: Dysregulation of circRNA_100876 expression leads to poor prognosis in ESCC by accelerating cell proliferation and metastasis.
Keywords: circRNA_100876, esophageal squamous cell carcinoma, metastasis, epithelial–mesenchymal transition
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