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Continuous noninvasive ventilation for respiratory failure in patients with amyotrophic lateral sclerosis: current perspectives

Authors Fiorentino G, Annunziata A, Gaeta AM, Lanza M, Esquinas A

Received 11 April 2018

Accepted for publication 31 May 2018

Published 4 September 2018 Volume 2018:8 Pages 55—61

DOI https://doi.org/10.2147/DNND.S170771

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Andrew Yee

Peer reviewer comments 4

Editor who approved publication: Prof. Dr. Thomas Müller


Giuseppe Fiorentino,1 Anna Annunziata,1 Anna Michela Gaeta,2 Maurizia Lanza,1 Antonio Esquinas3

1Division of Respiratory Physiopathology, Monaldi Hospital, Naples, Italy; 2Respiratory Department, Arnau de Vilanova and Santa Maria Universitary Hospital, IRBLleida, Lleida, Spain; 3Intensive Care Unit, Morales Meseguer Hospital, Murcia, Spain

Abstract: Respiratory failure is a recognized late complication of amyotrophic lateral sclerosis. It is related to the neurological progression of the diseases with the impairment of the respiratory musculature. Survival and quality of life of amyotrophic lateral sclerosis patients is improved by using noninvasive mechanical ventilation. The rate of long-term mechanical ventilation is different within and between countries. Cultural factors, socioeconomic conditions, and physician attitude often influence the decision to start noninvasive ventilation. Technical elements, like the choice of the correct interface, solid caregivers support, and the communication between the patient and the physician are essential for achieving therapeutic goals, especially in the case of continuous treatment.

Keywords: noninvasive ventilation, amyotrophic lateral sclerosis, respiratory failure, quality of life, adherence, interface, mouthpiece ventilation

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