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Consolidated bioprocessing for biofuel production: recent advances

Authors Mbaneme V, Chinn M

Received 13 December 2014

Accepted for publication 12 January 2015

Published 6 May 2015 Volume 2015:3 Pages 23—44


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Adolfo Perujo

Veronica Mbaneme-Smith, Mari S Chinn

Department of Biological and Agricultural Engineering, North Carolina State University, Raleigh, NC, USA

Abstract: Consolidated bioprocessing (CBP), the combination of saccharolytic enzyme production and secretion, hydrolysis of polysaccharides, and fermentation of available sugars within a single-unit operation, improves cellulose conversion efficiency and decreases lignocellulosic biomass processing costs for producing biofuels and value-added products. Clostridium thermocellum, an anaerobic, thermophilic bacterium is a significant biocatalyst aspirant for CBP, due to its native cellulolytic and ethanologenic capabilities. This review highlights strain development/modification, metabolic engineering, and process improvements associated with CBP in the context of using C. thermocellum as a model biocatalyst to reduce operating expenditures and inhibitory effects for enhanced biofuels production. In addition, opportunities in using a microbial consortia and biofilms are discussed. As an overview of recent advances in CBP technologies to convert lignocellulosic biomass to biofuels, this review gives researchers a platform for future development of efficient and sustainable CBP approaches.

Keywords: Clostridium thermocellum, cellulosome, anaerobic, cellulolytic, ethanol

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