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Comparison of Hematological and Biochemical Profile Changes in Pre- and Post-Chemotherapy Treatment of Cancer Patients Attended at Ayder Comprehensive Specialized Hospital, Mekelle, Northern Ethiopia 2019: A Retrospective Cohort Study

Authors Wondimneh B, Anekere Dasappa Setty S, Gebregzabher Asfeha G, Belay E, Gebremeskel G, Baye G

Received 30 July 2020

Accepted for publication 31 December 2020

Published 22 January 2021 Volume 2021:13 Pages 625—632

DOI https://doi.org/10.2147/CMAR.S274821

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Antonella D'Anneo


Bayu Wondimneh,1 Sathisha Anekere Dasappa Setty,2 Gebrekidan Gebregzabher Asfeha,2 Ezra Belay,2 Gidey Gebremeskel,2 Gelagay Baye1

1Department of Biomedical Sciences, Debre Markos University, Debre Markos, Ethiopia; 2Departments of Biochemistry and Molecular Biology, Mekelle University, Mekelle, Ethiopia

Correspondence: Bayu Wondimneh
Department of Biomedical Sciences, Debre Markos University, P.O. Box: 269, Debre Markos, Ethiopia
Tel +251 920031998
Fax +251 587780673
Email bayuwond@gmail.com

Purpose: This study aims to compare hematological and biochemical profile changes in pre- and post-chemotherapy among cancer patients admitted at the Oncology Unit of Ayder Comprehensive Specialized Hospital (ACSH), Mekelle, Northern Ethiopia.
Patients and Methods: A retrospective cohort study was conducted in 376 cancer patients admitted in the Oncology Unit at ACSH. Demographic data, hematological and biochemical profiles were collected from smart care and patient cards. The data were analyzed using SPSS version 20 statistical package. Descriptive statistics and paired sample students T-test statistical methods were used.
Results: From 376 study subjects, 228 (60.6%) were females. All the hematological profiles, except lymphocyte (LYM) (P > 0.05), showed significant decrement in post-chemotherapy compared to pre-chemotherapy; white blood cell (WBC) (P < 0.01), red blood cell (RBC) (P < 0.01), hemoglobin (Hb) (P< 0.001), hematocrit (HCT) (P < 0.05), platelet (PLT) (P < 0.001) and neutrophil (NUT) (P < 0.05). The biochemical profiles showed that blood urea nitrogen and creatinine levels were non-significantly decreased, urea (P > 0.05) and creatinine (CR) (P > 0.05), in post-chemotherapy compared to pre-chemotherapy whereas alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were non significantly increased, ALT (P > 0.05) and AST (P> 0. 05), in post-chemotherapy compared to pre-chemotherapy.
Conclusion: Hematological profiles, except lymphocytes, were found significantly decreased whereas biochemical profiles, urea, and creatinine were decreased non-significantly, while AST and ALT showed non-significant increments in post-chemotherapy compared to pre-chemotherapy.

Keywords: cancer, chemotherapy, hematological profiles, biochemical profiles, Ethiopia

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