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Comparative diagnostic accuracy of ACE-III and MoCA for detecting mild cognitive impairment

Authors Wang BR, Zheng HF, Xu C, Sun Y, Zhang YD, Shi JQ

Received 15 April 2019

Accepted for publication 12 August 2019

Published 13 September 2019 Volume 2019:15 Pages 2647—2653

DOI https://doi.org/10.2147/NDT.S212328

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Prof. Dr. Roumen Kirov

Peer reviewer comments 2

Editor who approved publication: Dr Yu-Ping Ning


Bian-Rong Wang,1 Hui-Fen Zheng,1 Chang Xu,1 Yi Sun,1 Ying-Dong Zhang,2 Jian-Quan Shi2

1Department of Neurology, Geriatric Hospital of Nanjing Medical University, Nanjing, Jiangsu Province 210024, People’s Republic of China; 2Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu Province 210006, People’s Republic of China

Correspondence: Ying-Dong Zhang; Jian-Quan Shi
Department of Neurology, Nanjing First Hospital, Nanjing Medical University, No. 68, Changle Road, Nanjing, Jiangsu Province 210006, People’s Republic of China
Tel +86 0 258 772 6218; +86 0 258 772 6224
Email zhangyingdong@aliyun.com; myxiyi_0717@163.com

Objective: The aim of this study was to validate the reliability of the Chinese version of Addenbrooke’s Cognitive Examination III (ACE-III) for detecting mild cognitive impairment. Furthermore, the present study compares the diagnostic accuracy of ACE-III with that of Montreal Cognitive Assessment (MoCA).
Methods: One hundred and twenty patients with MCI and 136 healthy controls were included in the study. All patients were evaluated by the Chinese version of ACE-III, MoCA and MMSE.
Results: Subjects in the control group showed better performance in ACE-III total score and its subdomain scores than those in the MCI group. There was a significantly positive correlation between ACE-III total score and MoCA score. Meanwhile, there was also a significantly positive correlation between ACE-III total score and MMSE score. For ACE-III total score, a cut-off point of 85 yielded a sensitivity of 97.3% and a specificity of 90.7%. The AUC for ACE-III total score was 0.978. For MoCA, a cut-off point of 23 yielded a sensitivity of 86.5% and a specificity of 97.7%. The AUC for MoCA was 0.961. There were no significant differences in diagnostic accuracy between ACE-III and MoCA.
Conclusion: The present findings support that both ACE-III and MoCA are useful for detecting MCI in early stages.

Keywords: Addenbrooke’s Cognitive Examination III, Montreal Cognitive Assessment, mild cognitive impairment, cognitive screening, Chinese

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