Back to Journals » International Journal of General Medicine » Volume 7

Community-acquired pneumonia caused by carbapenem-resistant Streptococcus pneumoniae: re-examining its prevention and treatment

Authors Doi A, Iwata K, Takegawa H, Miki K, Sono Y, Nishioka H, Takeshita J, Tomii K, Haruta T

Received 8 March 2014

Accepted for publication 2 April 2014

Published 21 May 2014 Volume 2014:7 Pages 253—257


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Asako Doi,1,2 Kentaro Iwata,3 Hiroshi Takegawa,4 Kanji Miki,5 Yumi Sono,1,2 Hiroaki Nishioka,2 Jumpei Takeshita,6 Keisuke Tomii,7 Tsunekazu Haruta1

1Department of Infectious Diseases, 2Department of General Internal Medicine, Kobe City Medical Center General Hospital, 3Division of Infectious Diseases, Kobe University Hospital, Japan; 4Department of Laboratory Medicine, Kobe City Medical Center General Hospital, Japan; 5Hyogo Health Service Association, Hyogo, 6Foundation of Biochemical Research and Innovation, Osaka, 7Department of Pulmonary Medicine, Kobe City Medical Center General Hospital, Hyogo, Japan

Abstract: A 73-year-old man with no significant past medical history or any history of health care visits was hospitalized for pneumonia. Sputum culture revealed multidrug-resistant Streptococcus pneumoniae, even to carbapenems. The patient was later treated successfully with levofloxacin. Throat cultures from his two grandchildren revealed S. pneumoniae with the same susceptibility pattern. Analysis for resistant genes revealed gPRSP (pbp1a + pbp2x + pbp2b gene variants) in both the patient and his grandchildren, none of whom had received pneumococcal vaccines of any kind. This case illustrates the importance of the emergence of carbapenem-resistant S. pneumoniae. Non-rational use of carbapenems for community-acquired infections may be counterproductive. This case also highlights the importance of pneumococcal vaccinations in children and the elderly.

Keywords: carbapenem resistance, Streptococcus pneumoniae, pneumonia

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]


Other articles by this author:

Interstitial nephritis caused by HIV infection by itself: a case report

Doi A, Iwata K, Hara S, Imai Y, Hasuike T, Nishioka H

International Journal of General Medicine 2016, 9:311-314

Published Date: 1 September 2016

A case of polymyalgia rheumatica following influenza B infection

Iwata K, Mizuno Y

International Journal of General Medicine 2015, 8:345-347

Published Date: 21 October 2015

38-year-old woman with recurrent abdominal pain, but no fever

Iwata K, Toma T, Yachie A

International Journal of General Medicine 2012, 5:265-268

Published Date: 22 March 2012

Readers of this article also read:

Emerging and future therapies for hemophilia

Carr ME, Tortella BJ

Journal of Blood Medicine 2015, 6:245-255

Published Date: 3 September 2015

Green synthesis of water-soluble nontoxic polymeric nanocomposites containing silver nanoparticles

Prozorova GF, Pozdnyakov AS, Kuznetsova NP, Korzhova SA, Emel’yanov AI, Ermakova TG, Fadeeva TV, Sosedova LM

International Journal of Nanomedicine 2014, 9:1883-1889

Published Date: 16 April 2014

Methacrylic-based nanogels for the pH-sensitive delivery of 5-Fluorouracil in the colon

Ashwanikumar N, Kumar NA, Nair SA, Kumar GS

International Journal of Nanomedicine 2012, 7:5769-5779

Published Date: 15 November 2012

A novel preparation method for silicone oil nanoemulsions and its application for coating hair with silicone

Hu Z, Liao M, Chen Y, Cai Y, Meng L, Liu Y, Lv N, Liu Z, Yuan W

International Journal of Nanomedicine 2012, 7:5719-5724

Published Date: 12 November 2012

Cross-linked acrylic hydrogel for the controlled delivery of hydrophobic drugs in cancer therapy

Deepa G, Thulasidasan AK, Anto RJ, Pillai JJ, Kumar GS

International Journal of Nanomedicine 2012, 7:4077-4088

Published Date: 27 July 2012

Crystallization after intravitreal ganciclovir injection

Pitipol Choopong, Nattaporn Tesavibul, Nattawut Rodanant

Clinical Ophthalmology 2010, 4:709-711

Published Date: 14 July 2010