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Clinicopathological characteristics, treatment, and survival outcomes of cystadenocarcinoma of the salivary gland: a population-based study

Authors Cai CF, Sun JY, He Z, Lin HX, Liu FR, Wang Y

Received 23 April 2016

Accepted for publication 1 September 2016

Published 25 October 2016 Volume 2016:9 Pages 6569—6572

DOI https://doi.org/10.2147/OTT.S111247

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Manfred Beleut

Peer reviewer comments 2

Editor who approved publication: Professor Jianmin Xu


Cheng-Fu Cai,1,2,* Jia-Yuan Sun,3,* Zhen-Yu He,3 Huan-Xin Lin,3 Fa-Rong Liu,2,4 Yan Wang3

1Department of Otolaryngology-Head and Neck Surgery, Affiliated First Hospital, Medical College, Xiamen University, 2Teaching Hospital of Fujian Medical University, Xiamen, 3Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, 4Department of Psychology, Affiliated First Hospital, Medical College, Xiamen University, People’s Republic of China

*These authors contributed equally to this work

Background: The aim of this study was to investigate the clinicopathological characteristics, treatment, and survival of cystadenocarcinoma of the salivary gland.
Patients and methods: Cases in the Surveillance, Epidemiology, and End Results database from 1991 to 2012 were identified. Factors significantly associated with survival were identified using Kaplan–Meier survival analysis and Cox proportional hazard regression.
Results: A total of 65 patients were identified; of these patients, 64 received surgical treatment, 25 underwent lymphadenectomy, and four (16.0%) patients had nodal metastasis and only one (2.1%) patient had poorly differentiated disease. The most common tumor location was the parotid gland (87.7%). The median follow-up was 55 months. None of the patients died of salivary gland malignant-tumor-related disease. The 5- and 10-year cause-specific survival rates were 97.0% and 81.4%, respectively. The 5- and 10-year overall survival rates were 84.6% and 60.7%, respectively. Surgical procedures, lymphadenectomy, and adjuvant radiotherapy did not affect survival.
Conclusion: Salivary gland cystadenocarcinoma is extremely rare but has an excellent prognosis, and surgery is the mainstay of treatment.

Keywords: cystadenocarcinoma, salivary gland, SEER, treatment, survival

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