Clinicopathological Characteristics and Prognosis of Breast Cancer in Young Women – A Single Center Study in a Developing Country
Authors Sun X, Liu J, Ji H, Yang M, Lu Y
Received 24 December 2020
Accepted for publication 28 January 2021
Published 17 February 2021 Volume 2021:13 Pages 1601—1607
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 4
Editor who approved publication: Dr Eileen O'Reilly
Xiaoliang Sun, Jun Liu, Haoyang Ji, Meng Yang, Yao Lu
Department of General Surgery, China-Japan Friendship Hospital, Beijing, People’s Republic of China
Correspondence: Yao Lu
Department of General Surgery, China-Japan Friendship Hospital, No. 2 Yinghua East Road, Chaoyang District, Beijing, 100029, People’s Republic of China
Objective: Breast cancer (BC) in young women tends to be more aggressive. This study highlights the clinicopathological features and outcomes of young breast cancer (YBC) patients in a developing country.
Methods: Consecutive patients aged 35 years or younger with a pathologically confirmed diagnosis of breast cancer treated and followed up at our department were included. Medical records and follow-up databases were reviewed and documented.
Results: The rate of breast conservation and reconstruction surgery is higher in YBC patients. YBC patients are more likely to have tumors over 5cm, high-grade, hormone receptor negative, triple negative and stage III than old patients. There was no statistically significant difference in the pathological type, lymph node metastasis, and HER2 status. The median follow-up time was 96 months. The disease-free survival (DFS) was significantly worse in the YBC group. However, the overall survival (OS) had no difference between the two groups.
Conclusion: YBC patients had more aggressive pathological features, such as hormone receptor negative, triple negative, high-grade and advanced stage, and poorer DFS than the old counterparts.
Keywords: young age, breast cancer, clinicopathological characteristics, survival, molecular subtypes
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