Back to Journals » Cancer Management and Research » Volume 13

Clinicopathological Characteristics and Prognosis of Breast Cancer in Young Women – A Single Center Study in a Developing Country

Authors Sun X, Liu J, Ji H, Yang M, Lu Y

Received 24 December 2020

Accepted for publication 28 January 2021

Published 17 February 2021 Volume 2021:13 Pages 1601—1607

DOI https://doi.org/10.2147/CMAR.S299066

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 4

Editor who approved publication: Dr Eileen O'Reilly


Xiaoliang Sun, Jun Liu, Haoyang Ji, Meng Yang, Yao Lu

Department of General Surgery, China-Japan Friendship Hospital, Beijing, People’s Republic of China

Correspondence: Yao Lu
Department of General Surgery, China-Japan Friendship Hospital, No. 2 Yinghua East Road, Chaoyang District, Beijing, 100029, People’s Republic of China
Email zrluyao@163.com

Objective: Breast cancer (BC) in young women tends to be more aggressive. This study highlights the clinicopathological features and outcomes of young breast cancer (YBC) patients in a developing country.
Methods: Consecutive patients aged 35 years or younger with a pathologically confirmed diagnosis of breast cancer treated and followed up at our department were included. Medical records and follow-up databases were reviewed and documented.
Results: The rate of breast conservation and reconstruction surgery is higher in YBC patients. YBC patients are more likely to have tumors over 5cm, high-grade, hormone receptor negative, triple negative and stage III than old patients. There was no statistically significant difference in the pathological type, lymph node metastasis, and HER2 status. The median follow-up time was 96 months. The disease-free survival (DFS) was significantly worse in the YBC group. However, the overall survival (OS) had no difference between the two groups.
Conclusion: YBC patients had more aggressive pathological features, such as hormone receptor negative, triple negative, high-grade and advanced stage, and poorer DFS than the old counterparts.

Keywords: young age, breast cancer, clinicopathological characteristics, survival, molecular subtypes

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]