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Clinical utility of Raman spectroscopy: current applications and ongoing developments

Authors McGregor H, Wang W, Short M, Zeng H

Received 16 September 2015

Accepted for publication 22 January 2016

Published 22 June 2016 Volume 2016:2 Pages 13—29


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Utkan Demirci

Video abstract presented by McGregor and Wang.

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Hanna C McGregor,1 Wenbo Wang,1,2 Michael A Short,1 Haishan Zeng,1,3
1Integrative Oncology Department, BC Cancer Agency Research Centre, 2Department of Biomedical Engineering, 3Department of Dermatology, The University of British Columbia, Vancouver, BC, Canada

Abstract: Availability of fast, noninvasive/minimally invasive, and accurate diagnostic tests can maximize the benefit of patient care. The application of Raman spectroscopy (RS) in biological and biomedical applications has surged recently as a result of technological advancements in instrumentation and spectral data handling techniques. With maturation, the potential of RS in clinical diagnosis of various diseases, in particular, early cancer, has been widely explored and reported. This paper provides an introduction to the Raman theory and technology behind RS for nonspecialists interested in its clinical uses. Latest achievements in oncological, cardiovascular, and neurological applications of RS along with its clinical implementations are discussed.

Keywords: Biomedical optics, clinical diagnosis, early detection, cancer, cardiology, neurology

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