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Circulating syndecan-1 as a novel biomarker relates to lung function, systemic inflammation, and exacerbation in COPD

Authors Li D, Wu Y, Guo S, Qin J, Feng M, An Y, Zhang J, Li Y, Xiong S, Zhou H, Zeng Q, Chen L, Wen F

Received 7 March 2019

Accepted for publication 12 July 2019

Published 28 August 2019 Volume 2019:14 Pages 1933—1941

DOI https://doi.org/10.2147/COPD.S207855

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Prof. Dr. Chunxue Bai


Diandian Li,1,* Yanqiu Wu,1,* Shujin Guo,2,* Jiangyue Qin,1 Mei Feng,1 Yunfei An,3 Junlong Zhang,3 Yanping Li,4 Shuguang Xiong,5 Hui Zhou,6 Qianglin Zeng,6 Lei Chen,1 Fuqiang Wen1

1Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Chengdu 610041, People’s Republic of China; 2Department of Internal Medicine, Sichuan Provincial People’s Hospital and Sichuan Academy of Medical Science, Chengdu 610072, People’s Republic of China; 3Department of Laboratorial Medicine, West China Hospital of Sichuan University, Chengdu 610041, People’s Republic of China; 4Department of Respiratory and Critical Care Medicine, The 3rd People’s Hospital of Chengdu, Chengdu 610031, People’s Republic of China; 5Department of Respiratory and Critical Care Medicine, 416 Hospital, Chengdu 610051, People’s Republic of China; 6Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Chengdu University, Chengdu 610081, People’s Republic of China

Correspondence: Lei Chen; Fuqiang Wen
Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Chengdu 610041, People’s Republic of China
Tel +86 288 542 2350
Fax +86 288 558 2944
Email [email protected]; [email protected]

*These authors contributed equally to this work

Introduction: Patients with COPD often show increased systemic inflammation which is associated with lower functional status, greater exacerbation risk, and worse clinical outcomes. Syndecans (SDCs), a family of transmembrane heparan sulfate proteoglycans (HSPGs), have been found to involve in inflammatory processes in many chronic inflammatory diseases. The aim of this preliminary clinical study was to investigate the possible association between two SDCs, SDC-1 and SDC-4, with lung function, systemic inflammation, and risk of exacerbations in COPD patients.
Method: Serum SDC-1 and SDC-4 levels were measured in 101 COPD patients and 57 health controls. Correlations between SDCs and other parameters were analyzed using Spearsman’s rho. Receiver operating curve (ROC) analysis was used to evaluate the threshold value in differentiating disease status.
Results: Although both serum SDC-1 and SDC-4 showed a downward trend in COPD patients, only SDC-1 levels were correlated positively with the ratio of FEV1/FVC and parameters of small airway obstruction. Besides, SDC-1 but not SDC-4, was negatively correlated with C-reactive protein (CRP) in COPD patients and downregulated in frequent exacerbators (FEs) of COPD. Using a cutoff value of 2.08 ng/mL, the sensitivity and specificity of SDC-1 to differentiate FE were 44% and 93.4%, respectively.
Conclusion: In conclusion, circulating SDC-1 may be a novel inflammatory biomarker associated with lung function and systemic inflammation in patients with COPD, which could also be useful to identify the risk of COPD exacerbation. Further studies should be performed to clarify the influences of SDC-1 on the pathogenesis and outcomes of COPD.

Keywords: syndecan, chronic obstructive pulmonary disease, systemic inflammation, exacerbation, biomarker

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