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Chemopreventive activity of sulforaphane

Authors Jiang X, Liu Y, Ma L, Ji R, Qu Y, Xin Y, Lv G

Received 14 November 2015

Accepted for publication 20 July 2018

Published 11 September 2018 Volume 2018:12 Pages 2905—2913

DOI https://doi.org/10.2147/DDDT.S100534

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Anastasios Lymperopoulos


Xin Jiang,1 Ye Liu,2 Lixin Ma,1 Rui Ji,3 Yaqin Qu,1 Ying Xin,4 Guoyue Lv5

1Department of Radiation Oncology, The First Hospital of Jilin University, Changchun 130021, China; 2Department of Pathobiology, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai 519000, China; 3Department of Internal Medicine, Florida Hospital, Orlando, FL, USA; 4Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun 130021, China; 5Department of General Surgery, The First Hospital of Jilin University, Changchun 130021, China

Abstract: Cancer is one of the major causes of morbidity and mortality in the world. Carcinogenesis is a multistep process induced by genetic and epigenetic changes that disrupt pathways controlling cell proliferation, apoptosis, differentiation, and senescence. In this context, many bioactive dietary compounds from vegetables and fruits have been demonstrated to be effective in cancer prevention and intervention. Over the years, sulforaphane (SFN), found in cruciferous vegetables, has been shown to have chemopreventive activity in vitro and in vivo. SFN protects cells from environmental carcinogens and also induces growth arrest and/or apoptosis in various cancer cells. In this review, we will discuss several potential mechanisms of the chemopreventive activity of SFN, including regulation of Phase I and Phase II drug-metabolizing enzymes, cell cycle arrest, and induction of apoptosis, especially via regulation of signaling pathways such as Nrf2-Keap1 and NF-κB. Recent studies suggest that SFN can also affect the epigenetic control of key genes and greatly influence the initiation and progression of cancer. This research may provide a basis for the clinical use of SFN for cancer chemoprevention and enable us to design preventive strategies for cancer management, reduce cancer development and recurrence, and thus improve patient survival.

Keywords: sulforaphane, tumor, chemoprevention, Phase I and Phase II drug-metabolizing enzymes, apoptosis, anti-inflammatory, cell cycle progression, epigenetics

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