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Cerium oxide nanoparticles in cancer

Authors Gao Y, Chen K, Ma J, Gao F

Received 6 February 2014

Accepted for publication 6 April 2014

Published 27 May 2014 Volume 2014:7 Pages 835—840

DOI https://doi.org/10.2147/OTT.S62057

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 6


Ying Gao,1 Kan Chen,2,* Jin-lu Ma,1,* Fei Gao3

1Department of Radiotherapy Oncology, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, People's Republic of China; 2School of Life Sciences, Zhejiang Sci-Tech University, Hangzhou, People's Republic of China; 3Department of Neurology, First Affiliated Hospital of Xi'an Medical University, Xi'an, People's Republic of China

*These authors contributed equally to this work

Abstract: With the development of many nanomedicines designed for tumor therapy, the diverse abilities of cerium oxide nanoparticles (CONPs) have encouraged researchers to pursue CONPs as a therapeutic agent to treat cancer. Research data have shown CONPs to be toxic to cancer cells, to inhibit invasion, and to sensitize cancer cells to radiation therapy and chemotherapy. CONPs also display minimal toxicity to normal tissues and provide protection from various forms of reactive oxygen species generation. Differential cytotoxicity is important for anticancer drugs to distinguish effectively between tumor cells and normal cells. The antioxidant capabilities of CONPs, which enable cancer therapy protection, have also resulted in the exploration of these particles as a potential anticancer treatment. Taken together, CONPs might be a potential nanomedicine for cancer therapy and this review highlights the current research into CONPs as a novel therapeutic for the treatment of cancer.

Keywords: cerium oxide nanoparticles, cancer treatment, radioprotection, radiosensitization

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