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Cannabidiol as a Novel Therapeutic for Immune Modulation

Authors Peyravian N, Deo S, Daunert S, Jimenez JJ

Received 21 June 2020

Accepted for publication 21 July 2020

Published 18 August 2020 Volume 2020:9 Pages 131—140

DOI https://doi.org/10.2147/ITT.S263690

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Professor Michael Shurin


Nadia Peyravian,1,2 Sapna Deo,1,2 Sylvia Daunert,1– 3 Joaquin J Jimenez1,2,4

1Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL, USA; 2Dr. JT Macdonald Foundation Biomedical Nanotechnology Institute of the University of Miami, Miami, FL, USA; 3University of Miami Clinical and Translational Science Institute, Miami, FL, USA; 4Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA

Correspondence: Joaquin J Jimenez; Sylvia Daunert
Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, 1011 NW 15th Street, Miami, FL 33136, USA
Tel +1 305 243 6586
Email j.jimenez@med.miami.edu; sdaunert@med.miami.edu

Abstract: The immune-suppressive effects of cannabidiol (CBD) are attributed to the modulation of essential immunological signaling pathways and receptors. Mechanistic understanding of the pharmacological effects of CBD emphasizes the therapeutic potential of CBD as a novel immune modulator. Studies have observed that the antagonists of CB1 and CB2 receptors and transient receptor potential vanilloid 1 reverse the immunomodulatory effects of CBD. CBD also inhibits critical activators of the Janus kinase/signal transducer and activator of transcription signaling pathway, as well as the nucleotide-binding oligomerization domain-like receptor signaling pathway, in turn decreasing pro-inflammatory cytokine production. Furthermore, CBD protects against cellular damage incurred during immune responses by modulating adenosine signaling. Ultimately, the data overwhelmingly support the immunosuppressive effects of CBD and this timely review draws attention to the prospective development of CBD as an effective immune modulatory therapeutic.

Keywords: cannabidiol, CBD, immune modulation, CB1 and CB2 receptors, TRPV1, JAK/STAT, inflammasome

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