Back to Journals » International Journal of Chronic Obstructive Pulmonary Disease » Volume 10 » Issue 1

Candidate genes for COPD: current evidence and research

Authors Kim WJ, Lee SD

Received 30 July 2015

Accepted for publication 25 September 2015

Published 19 October 2015 Volume 2015:10(1) Pages 2249—2255

DOI https://doi.org/10.2147/COPD.S80227

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Professor Hsiao-Chi Chuang

Peer reviewer comments 2

Editor who approved publication: Dr Richard Russell

Woo Jin Kim,1 Sang Do Lee2

1Department of Internal Medicine and Environmental Health Center, Kangwon National University, Chuncheon, 2Department of Pulmonary and Critical Care Medicine, Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea

Abstract: COPD is a common complex disease characterized by progressive airflow limitation. Several genome-wide association studies (GWASs) have discovered genes that are associated with COPD. Recently, candidate genes for COPD identified by GWASs include CHRNA3/5 (cholinergic nicotine receptor alpha 3/5), IREB2 (iron regulatory binding protein 2), HHIP (hedgehog-interacting protein), FAM13A (family with sequence similarity 13, member A), and AGER (advanced glycosylation end product–specific receptor). Their association with COPD susceptibility has been replicated in multiple populations. Since these candidate genes have not been considered in COPD, their pathological roles are still largely unknown. Herein, we review some evidences that they can be effective drug targets or serve as biomarkers for diagnosis or subtyping. However, more study is required to understand the functional roles of these candidate genes. Future research is needed to characterize the effect of genetic variants, validate gene function in humans and model systems, and elucidate the genes’ transcriptional and posttranscriptional regulatory mechanisms.

Keywords: chronic obstructive pulmonary disease, genetics, genome-wide association study

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Other article by this author:

Characteristics of stable chronic obstructive pulmonary disease patients in the pulmonology clinics of seven Asian cities

Oh YM, Bhome AB, Boonsawat W, Gunasekera KD, Madegedara D, Idolor L, Roa C, Kim WJ, Kuo HP, Wang CH, Lan LT, Loh LC, Ong CK, Ng A, Nishimura M, Makita H, Silverman EK, Lee JS, Yang T, Lin Y, Wang C, Lee SD

International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:31-39

Published Date: 14 January 2013

Readers of this article also read:

A new approach to assess COPD by identifying lung function break-points

Eriksson G, Jarenbäck L, Peterson S, Ankerst J, Bjermer L, Tufvesson E

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2193-2202

Published Date: 14 October 2015

Wheezing, a significant clinical phenotype of COPD: experience from the Taiwan Obstructive Lung Disease Study

Huang WC, Tsai YH, Wei YF, Kuo PH, Tao CW, Cheng SL, Lee CH, Wu YK, Chen NH, Hsu WH, Hsu JY, Wang CC, Lin MS

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2121-2126

Published Date: 7 October 2015

An efficient PEGylated liposomal nanocarrier containing cell-penetrating peptide and pH-sensitive hydrazone bond for enhancing tumor-targeted drug delivery

Ding Y, Sun D, Wang GL, Yang HG, Xu HF, Chen JH, Xie Y, Wang ZQ

International Journal of Nanomedicine 2015, 10:6199-6214

Published Date: 1 October 2015

Prevalence and risk factors for COPD in greenhouse farmers: a large, cross-sectional survey of 5,880 farmers from northeast China

Liu S, Ren YG, Wen DL, Chen Y, Chen DH, Li LY, Zhang XH, Zhang YB, Fu S, Li ZH, Xia SY, Wang DL, Chen H, Zhao J, Wang XG

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2097-2108

Published Date: 1 October 2015

Pathogens in COPD exacerbations identified by comprehensive real-time PCR plus older methods

Shimizu K, Yoshii Y, Morozumi M, Chiba N, Ubukata K, Uruga H, Hanada S, Saito N, Kadota T, Ito S, Wakui H, Takasaka N, Minagawa S, Kojima J, Hara H, Numata T, Kawaishi M, Saito K, Araya J, Kaneko Y, Nakayama K, Kishi K, Kuwano K

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2009-2016

Published Date: 23 September 2015

The relationship between anthropometric indicators and walking distance in patients with chronic obstructive pulmonary disease

Ho SC, Hsu MF, Kuo HP, Wang JY, Chen LF, Lee KY, Chuang HC

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1857-1862

Published Date: 8 September 2015

Association between vitamin D receptor polymorphisms and osteoporosis in patients with COPD

Kim SW, Lee JM, Ha JH, Kang HH, Rhee CK, Kim JW, Moon HS, Baek KH, Lee SH

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1809-1817

Published Date: 4 September 2015

Cardiovascular and inflammatory effects of simvastatin therapy in patients with COPD: a randomized controlled trial

John ME, Cockcroft JR, McKeever TM, Coward WR, Shale DJ, Johnson SR, Thornton JG, Harrison TW, Knox AJ, Bolton CE

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:211-221

Published Date: 29 January 2015