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Cancer Cell–Membrane Biomimetic Boron Nitride Nanospheres for Targeted Cancer Therapy

Authors Feng S, Ren Y, Li H, Tang Y, Yan J, Shen Z, Zhang H, Chen F

Received 22 June 2020

Accepted for publication 14 February 2021

Published 11 March 2021 Volume 2021:16 Pages 2123—2136


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 7

Editor who approved publication: Dr Mian Wang

Shini Feng,1 Yajing Ren,1 Hui Li,1 Yunfei Tang,1 Jinyu Yan,1 Zeyuan Shen,1 Huijie Zhang,2 Fuxue Chen1

1School of Life Sciences, Shanghai University, Shanghai, 200444, People’s Republic of China; 2School of Pharmaceutical Sciences, Jiangnan University, Wuxi, 214122, People’s Republic of China

Correspondence: Fuxue Chen
School of Life Sciences, Shanghai University, Shanghai, 200444, People’s Republic of China
Tel/Fax +86-21-6613-5167
Email [email protected]

Purpose: Nanomaterial-based drug-delivery systems allowing for effective targeted delivery of smallmolecule chemodrugs to tumors have revolutionized cancer therapy. Recently, as novel nanomaterials with outstanding physicochemical properties, boron nitride nanospheres (BNs) have emerged as a promising candidate for drug delivery. However, poor dispersity and lack of tumor targeting severely limit further applications. In this study, cancer cell–membrane biomimetic BNs were designed for targeted anticancer drug delivery.
Methods: Cell membrane extracted from HeLa cells (HM) was used to encapsulate BNs by physical extrusion. Doxorubicin (Dox) was loaded onto HM-BNs as a model drug.
Results: The cell-membrane coating endowed the BNs with excellent dispersibility and cytocompatibility. The drug-release profile showed that the [email protected] responded to acid pH, resulting in rapid Dox release. Enhanced cellular uptake of [email protected] by HeLa cells was revealed because of the homologous targeting of cancer-cell membranes. CCK8 and live/dead assays showed that [email protected] had stronger cytotoxicity against HeLa cells, due to self-selective cellular uptake. Finally, antitumor investigation using the HeLa tumor model demonstrated that [email protected] possessed much more efficient tumor inhibition than free Dox or [email protected]
Conclusion: These findings indicate that the newly developed HM-BNs are promising as an efficient tumor-selective drug-delivery vehicle for tumor therapy.

Keywords: boron nitride nanospheres, cancer-cell membrane, targeted drug delivery, chemotherapy, biomimetic

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