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Can resistive breathing injure the lung? Implications for COPD exacerbations

Authors Vassilakopoulos T, Toumpanakis D

Received 30 May 2016

Accepted for publication 1 August 2016

Published 26 September 2016 Volume 2016:11(1) Pages 2377—2384


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Richard Russell

Theodoros Vassilakopoulos, Dimitrios Toumpanakis

Pulmonary and Critical Care Medicine, Medical School, National and Kapodistrian University of Athens, Greece

Abstract: In obstructive lung diseases, airway inflammation leads to bronchospasm and thus resistive breathing, especially during exacerbations. This commentary discusses experimental evidence that resistive breathing per se (the mechanical stimulus) in the absence of underlying airway inflammation leads to lung injury and inflammation (mechanotransduction). The potential implications of resistive breathing-induced mechanotrasduction in COPD exacerbations are presented along with the available clinical evidence.

Keywords: resistive breathing, COPD, mechanotransduction, bronchoconstriction, inflammation

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