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Breast cancer laterality and molecular subtype likely share a common risk factor

Authors Cheng SA, Liang LZ, Liang QL, Huang ZY, Peng XX, Hong XC, Luo XB, Yuan GL, Zhang HJ, Jiang L

Received 1 August 2018

Accepted for publication 19 October 2018

Published 29 November 2018 Volume 2018:10 Pages 6549—6554

DOI https://doi.org/10.2147/CMAR.S182254

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Dr Rituraj Purohit


Shao-Ang Cheng,1,* Li-Zhong Liang,2,* Qi-Lian Liang,1 Zhen-Yi Huang,3 Xiao-Xia Peng,1 Xiao-Cui Hong,1 Xing-Bo Luo,1 Gao-Le Yuan,1 Hui-Jie Zhang,1 Liang Jiang4

1Oncology Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China; 2Medical Insurance Office, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China; 3Department of Finance, Central Hospital of Guangdong Agriculture Reclamation, Zhanjiang 524002, China; 4Interventional Ward, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China

*These authors contributed equally to this work

Background: To investigate the epidemiological features of breast cancer laterality and molecular subtypes in southern China.
Materials and methods: A total of 2,049 cases who were diagnosed with unilateral breast cancer in the past 5 years were classified based on laterality and molecular subtypes. Molecular subtypes were defined in accordance with the 2013 St. Gallen recommendations.
Results: Breast cancer was more likely to be diagnosed in the left breast than in the right at a rate of around 5%. In the case of invasive carcinomas, the right breast was more commonly affected than the left in young (<40 years old) patients (left-to-right [L:R] ratio 0.80, 95% CI 0.65, 0.98), whereas the opposite trend was found in old (≥40 years old) patients (L:R ratio 1.06, 95% CI 1.02, 1.73). Except for invasive mucinous and invasive medullary breast cancers, the other histological types occurred more frequently on the left side than on the right. In situ cancer with a defined subtype was likely to be diagnosed as luminal B(HER-2+). Except for invasive medullary and invasive nonspecific cancers, other invasive carcinomas with a defined subtype were most likely to be diagnosed as luminal B(HER-2–). The age of ≥40 years was a risk factor for luminal B(HER-2+), and a significant correlation was present between the right breast and luminal B(HER-2+).
Conclusion: We explored the risk factors of breast cancer laterality and various molecular subtypes and found that age may be a predictor of breast cancer laterality. We found that age and laterality are the probable risk factors of the luminal B(HER-2+) type of breast cancer. These results provide a basis for the epidemiological characterization of breast cancer.

Keywords:
epidemiology, breast carcinoma, tumor laterality, molecular subtype, histological type, risk factor, China

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