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Brain Metastases Completely Disappear in Non-Small Cell Lung Cancer Using Hydrogen Gas Inhalation: A Case Report

Authors Chen J, Mu F, Lu T, Du D, Xu K

Received 18 October 2019

Accepted for publication 28 November 2019

Published 17 December 2019 Volume 2019:12 Pages 11145—11151

DOI https://doi.org/10.2147/OTT.S235195

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 4

Editor who approved publication: Dr Federico Perche


Jibing Chen,1 Feng Mu,1 Tianyu Lu,1 Duanming Du,2 Kecheng Xu1

1Fuda Cancer Hospital of Jinan University, Guangzhou 510665, People’s Republic of China; 2Intervention Department of Shenzhen Second People’s Hospital, Shenzhen 518035, People’s Republic of China

Correspondence: Kecheng Xu
Fuda Cancer Hospital of Jinan University, No. 2 of Tangde West Road, Tianhe District, Guangzhou 510665, People’s Republic of China
Email xukc@vip.163.com
Duanming Du
Intervention Department of Shenzhen Second People’s Hospital, No. 3002 of Sungang West Road, Futian District, Shenzhen 518035, People’s Republic of China
Email 13068872049@163.com

Abstract: Lung cancer is the most common type of tumor, prone to contralateral lung, bone and brain metastasis. We report a 44-year-old woman diagnosed with lung cancer with multiple metastases in November 2015. Oral targeted drugs were initiated after the removal of brain metastases, and most lesions remained stable for 28 months. In March 2018, intracranial multiple metastases, as well as hydrocephalus accumulation in the third ventricle and lateral ventricles, and metastases in bone, adrenal gland, liver were noted. Hydrogen-gas monotherapy was started to control the tumor a month later. After 4 months, the size of multiple brain tumors was reduced significantly, and the amount of hydrocephalus in the third ventricle and lateral ventricles reduced significantly. After 1 year, all brain tumors had disappeared, and there were no significant changes in metastases in the liver and lung. These data show that, after standard treatments had failed, hydrogen-gas monotherapy elicited significant effective control of tumors (especially those in the brain), and survival time was lengthened.

Keywords: hydrogen gas, lung cancer, brain metastasis, extrapulmonary metastasis
 

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