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Both ipsilateral and contralateral localized vibratory stimulations modulated pain-related sensory thresholds on the foot in mice and humans

Authors Doi A, Sakasaki J, Tokunaga C, Sugita F, Kasae S, Nishimura K, Sato Y, Kuratsu T, Hashiguchi S, Shin MC, Yoshimura M

Received 12 January 2018

Accepted for publication 8 June 2018

Published 28 August 2018 Volume 2018:11 Pages 1645—1657

DOI https://doi.org/10.2147/JPR.S162379

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Erica Wegrzyn


Atsushi Doi,1,2,* Juntaro Sakasaki,3,* Chikato Tokunaga,4,* Fumiya Sugita,5,* Syota Kasae,6 Keisuke Nishimura,7 Yushi Sato,8 Takako Kuratsu,9 Sariya Hashiguchi,10 Min-Chul Shin,1,2 Megumu Yoshimura11

1Department of Physical Therapy, Kumamoto Health Science University, Kumamoto, Japan; 2Graduate School of Health Sciences, Kumamoto Health Science University, Kumamoto, Japan; 3Department of Rehabilitation, Tokyo-Wangan Rehabilitation Hospital, Narashino, Japan; 4Department of Rehabilitation, Himeno Hospital, Yame, Japan; 5Department of Rehabilitation, Tamana Central Hospital, Tamana, Japan; 6Department of Rehabilitation, Shimizu Hospital, Kyoto, Japan; 7Department of Rehabilitation, Iizuka Hospital, Iizuka, Japan; 8Department of Rehabilitation, Showa Hospital, Shimonoseki, Japan; 9Department of Rehabilitation, Konan Hospital, Kumamoto, Japan; 10Department of Rehabilitation, Asahino-Sogo Hospital, Kumamoto, Japan; 11Nakamura Hospital, Nogata, Japan

*These authors contributed equally to this work

Purpose: This study was aimed to investigate the effect of localized vibration on sensory thresholds in mice and humans using a novel quantitative method.
Participants and methods: The sensory thresholds of 7-week-old male C57BL/6J mice were measured with four sine-wave electrostimulation frequencies (5, 50, 250, and 2,000 Hz) before and after applying 2-minute vibration to the plantar side of the foot in mice. In human participants (16 males and 16 females; mean age, 21.0±0.8 years), the sensory threshold was measured at 50 Hz before and after applying 2-minute and 5-minute vibrations to the dorsal side of the foot.
Results: Application of a 2-minute vibration at either the ipsilateral or contralateral side modulated the sensory thresholds elicited by a 5- or 50-Hz right electrostimulation in mice. In human participants, application of a 5-minute vibration at either the ipsilateral or contralateral side modulated the sensory threshold elicited by 50-Hz right electrostimulation, but had no effect on local skin temperature. These results suggest that the right side of pain-related Aδ fibers (50 Hz) or C fibers (5 Hz) was modulated by the localized ipsilateral or contralateral side of vibratory stimuli, respectively, in mice and humans.
Conclusion: The ability of contralateral vibration to modify the right sensory thresholds suggests possible involvement of the central nervous system in vibratory modulation.

Keywords: vibration, sensory threshold, electrostimulation, central modulation

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