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Biomarkers of multiple sclerosis: current findings

Authors Harris VK, Tuddenham JF, Sadiq SA

Received 2 September 2016

Accepted for publication 8 December 2016

Published 12 January 2017 Volume 2017:7 Pages 19—29

DOI https://doi.org/10.2147/DNND.S98936

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Lucy Goodman

Peer reviewer comments 5

Editor who approved publication: Prof. Dr. Thomas Müller

Violaine K Harris, John F Tuddenham, Saud A Sadiq

Tisch Multiple Sclerosis Research Center of New York, New York, NY, USA

Abstract: Multiple sclerosis (MS) is an autoimmune disease affecting the brain and spinal cord that is associated with chronic inflammation leading to demyelination and neurodegeneration. With the recent increase in the number of available therapies for MS, optimal treatment will be based on a personalized approach determined by an individual patient’s prognosis and treatment risks. An integral part of such therapeutic decisions will be the use of molecular biomarkers to predict disability progression, monitor ongoing disease activity, and assess treatment response. This review describes current published findings within the past 3 years in biomarker research in MS, specifically highlighting recent advances in the validation of cerebrospinal fluid biomarkers such as neurofilaments (light and heavy chains), chitinases and chitinase 3-like proteins, soluble surface markers of innate immunity, and oligoclonal immunoglobulin M antibodies. Current research in circulating miRNAs as biomarkers of MS is also discussed. Continued validation and testing will be required before MS biomarkers are routinely applied in a clinical setting.

Keywords: multiple sclerosis, biomarkers, cerebrospinal fluid, neurofilament, miRNA

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