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Biomarkers of cardiac function and outcome in univentricular congenital heart disease

Authors Bernstein H, Nawaytou H

Received 7 March 2014

Accepted for publication 12 April 2014

Published 3 June 2014 Volume 2014:4 Pages 53—59

DOI https://doi.org/10.2147/CBF.S63713

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2


Harold S Bernstein,1,2 Hythem Nawaytou3

1Merck Sharp & Dohme Corp, Whitehouse Station, NJ, USA; 2The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; 3Department of Pediatrics, University of California, San Francisco, CA, USA

Abstract: A biomarker is a clinical characteristic that predicts the presence of a specific physiological state, degree of severity of a pathophysiological state, or long-term outcome resulting from that state. Broadly defined, a biomarker can be a clinical parameter, or the result of a biochemical assay or imaging measure. Children are imperfect historians and cardiac disease may mimic other organ system diseases. Hence, reliable biomarkers can greatly enhance diagnosis and management of pediatric cardiac disease. In this review, we discuss the use of biomarkers in managing complex congenital heart disease characterized by single ventricle physiology.

Keywords: biomarker, natriuretic peptide, heart failure, congenital heart disease, single ventricle


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