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Benefit effect of REM-sleep deprivation on memory impairment induced by intensive exercise in male wistar rats: with respect to hippocampal BDNF and TrkB

Authors Mahboubi S, Nasehi M, Imani A, Sadat-Shirazi MS, Zarrindast MR, Vousooghi N, Noroozian M

Received 2 March 2019

Accepted for publication 29 July 2019

Published 24 September 2019 Volume 2019:11 Pages 179—188

DOI https://doi.org/10.2147/NSS.S207339

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr Sutapa Mukherjee


Sarah Mahboubi,1 Mohammad Nasehi,2 Alireza Imani,3,4 Mitra-Sadat Sadat-Shirazi,1–5 Mohammad-Reza Zarrindast,5–7 Nasim Vousooghi,1 Maryam Noroozian1–8

1Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran; 2Department of Cognitive and Neuroscience Research Center (CNRC), Amir-Almomenin Hospital, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran; 3Department of Physiology, School of Medicine, Tehran University of Medical Science, Tehran, Iran; 4Department of Occupational Sleep Research Center, Tehran University of Medical Sciences, Tehran, Iran; 5Department of Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran; 6Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; 7Department of Endocrinology and Metabolism Research Institute, Tehran University of Medical Science, Tehran, Iran; 8Memory and Behavioral Neurology Division, Department of Psychiatry, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran

Correspondence: Maryam Noroozian
Memory and Behavioral Neurology Division, Department of Psychiatry, Roozbeh Hospital, Tehran University of Medical Sciences, South Kargar Avenue, P.O. Box 1333795914, Tehran, Iran
Tel +98 21 55 419 1515
Fax +98 21 5 541 9113
Email mnoroozi@tums.ac.ir

Background: Many factors affect our learning and memory quality, but according to different studies, having a positive or negative impact pertains to their characteristics like intensity or the amount.
Purpose: The present study was conducted to investigate the effect of 24-hour REM-sleep deprivation on continuous-high intensity forced exercise-induced memory impairment and its effect on Brain-Derived Neurotrophic Factor (BDNF) and Tyrosine kinase B (TrkB) levels in the hippocampus and Prefrontal Cortex area (PFC).
Material and methods: Animals were conditioned to run on treadmills for 5 weeks then, were deprived of sleep for 24 h using the modified multiple platforms. The effect of intensive exercise and/or 24-h REM-SD was studied on behavioral performance using Morris Water Maze protocol for 2 days, and BDNF/TrkB levels were assessed in hippocampus and PFC after behavioral probe test using western blotting.
Results: After 5 weeks of intensive exercise and 24-h REM-SD, spatial memory impairment and reduction of BDNF and TrkB levels were found in hippocampus and PFC. 24-h REM-SD improved memory impairment and intensive exercise-induced downregulation of BDNF and TrkB protein levels.
Conclusion: The results of the study suggested that sleep deprivation might act as a compensatory factor to reduce memory impairment when the animal is under severe stressful condition.

Keywords: intensive exercise, sleep deprivation, spatial memory, hippocampus, prefrontal cortex, BDNF, TrkB

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