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BCOR mutation and TLS-ERG expression in acute myeloid leukemia with monoclonal immunoglobulinemia

Authors Jin J, Luo S, Ye X, Huang J

Received 9 June 2019

Accepted for publication 8 August 2019

Published 2 September 2019 Volume 2019:12 Pages 7123—7127

DOI https://doi.org/10.2147/OTT.S218805

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Prof. Dr. Nicola Silvestris


Jingxia Jin, Shuna Luo, XingNong Ye, Jian Huang

Department of Hematology, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, Zhejiang 322000, People’s Republic of China

Correspondence: Jian Huang
Department of Hematology, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, N1 Shangcheng Road, Yiwu, Zhejiang 322000, People’s Republic of China
Tel +86 1 886 796 1032
Fax +86 5 798 993 5555
Email househuang@zju.edu.cn

Abstract: Acute myeloid leukemia (AML) originates from the abnormal clonal proliferation of myeloblasts. Immunoglobulin is secreted by B cells. AML with monoclonal antibody often indicates a poor prognosis. Here we report a case of BCOR mutation and TLS-ERG expression in AML with monoclonal immunoglobulinemia. After chemotherapy, the patient achieved bone marrow complete remission. BCOR mutation and TLS-ERG fusion gene in patient’s bone marrow were not detected, at the same time, peripheral blood monoclonal immunoglobulin also disappeared. BCOR mutation or TLS-ERG fusion gene expression is associated with poor prognosis, AML with monoclonal immunoglobulin may have the same prognostic significance.

Keywords: acute myeloid leukemia, bone marrow, monoclonal immunoglobulin, TLS-ERG, BCOR

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