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Bacteriophage – A Promising Alternative Measure for Bacterial Biofilm Control

Authors Tian F, Li J, Nazir A, Tong Y

Received 3 November 2020

Accepted for publication 23 December 2020

Published 20 January 2021 Volume 2021:14 Pages 205—217

DOI https://doi.org/10.2147/IDR.S290093

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Professor Suresh Antony


Fengjuan Tian,* Jing Li,* Amina Nazir, Yigang Tong

Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Yigang Tong Email tong.yigang@gmail.com

Abstract: Bacterial biofilms can enhance bacteria’s viability by providing resistance against antibiotics and conventional disinfectants. The existence of biofilm is a serious threat to human health, causing incalculable loss. Therefore, new strategies to deal with bacterial biofilms are needed. Bacteriophages are unique due to their activity on bacteria and do not pose a threat to humans. Consequently, they are considered safe alternatives to drugs for the treatment of bacterial diseases. They can effectively obliterate bacterial biofilms and have great potential in medical treatment, the food industry, and pollution control. There are intricate mechanisms of interaction between phages and biofilms. Biofilms may prevent the invasion of phages, and phages can kill bacteria for biofilm control purposes or influence the formation of biofilms. At present, there are various measures for the prevention and control of biofilms through phages, including the combined use of drugs and the application of phage cocktails. This article mainly reviews the function and formation process of bacterial biofilms, summarizes the different mechanisms between phages and biofilms, briefly explains the phage usage for the control of bacterial biofilms, and promotes phage application maintenance human health and the protection of the natural environment.

Keywords: biofilm, phage, drug-resistant bacteria, antibiotic substitute, bacterial biofilm control

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