Other papers submitted by: Dr Juan C. Arévalo

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Paper published by Dr Juan C. Arévalo:

Review

Noteworthy comment: Voltage-gated ion channels are important factors in determining tissue excitability and are increasingly seen as potential targets for the treatment of new drugs in disorders such as epilepsy and cardiac dysfunction. This review focusses on the regulation of several varieties of voltage-gated channels, including sodium, potassium and chloride channels as well as related proteins, by the E3 ubiquitin ligase Nedd4-2. As such this is a novel and valuable summary and perspective of a rapidly growing field. It also serves to emphasise the potential therapeutic value of targeting new drugs on molecules that regulate channel function in addition to the channels themselves.

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Nedd4-2 regulation of voltage-gated ion channels: an update on structure–function relationships and the pathophysiological consequences of dysfunction

Arévalo JC

Journal of Receptor, Ligand and Channel Research 2015, 8:53-63

Published Date: 18 August 2015