Other papers submitted by: Dr Linda Wase

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Papers published by Dr Linda Wase:

Original Research

Noteworthy comment: Great example of clinical use of a compound demonstrating agonist directed trafficking- reduced recruitment of b-arrestin. This is particularly relevant in the current climate as this study focuses on an opioid agonist that could yield less development of tolerance in the real world and possibly lead to a lower required dose. This is extremely relevant for all of those involved in pain treatment.

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ATHENA: A Phase 3, Open-Label Study Of The Safety And Effectiveness Of Oliceridine (TRV130), A G-Protein Selective Agonist At The μ-Opioid Receptor, In Patients With Moderate To Severe Acute Pain Requiring Parenteral Opioid Therapy

Bergese SD, Brzezinski M, Hammer GB, Beard TL, Pan PH, Mace SE, Berkowitz RD, Cochrane K, Wase L, Minkowitz HS, Habib AS

Journal of Pain Research 2019, 12:3113-3126

Published Date: 14 November 2019

Original Research

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Plain language summary

APOLLO-1: a randomized placebo and active-controlled phase III study investigating oliceridine (TRV130), a G protein-biased ligand at the µ-opioid receptor, for management of moderate-to-severe acute pain following bunionectomy

Viscusi ER, Skobieranda F, Soergel DG, Cook E, Burt DA, Singla N

Journal of Pain Research 2019, 12:927-943

Published Date: 11 March 2019