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Attributing diseases to multiple pathways: a causal-pie modeling approach

Authors Chen C, Lee WC

Received 18 December 2017

Accepted for publication 8 March 2018

Published 27 April 2018 Volume 2018:10 Pages 489—497


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Professor Irene Petersen

Christine Chen,1 Wen-Chung Lee1,2

1Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan; 2Research Center for Genes, Environment and Human Health, College of Public Health, National Taiwan University, Taipei, Taiwan

Abstract: Characterizing the relations between exposures and diseases is the central tenet of epidemiology. Researchers may want to evaluate exposure-disease causation by assessing whether the disease under concern is induced by the various exposures – the so-called “attribution”. In this paper, the authors propose a method to attribute diseases to multiple pathways based on the causal-pie model. The method can also be used to evaluate the potential impact of an intervention strategy and to allocate responsibility in tort-law liability issues.

Keywords: epidemiological methods, attribution, disease pathways, causal-pie model

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