Back to Journals » Cancer Management and Research » Volume 10

Association study of genetic variation of lncRNA MALAT1 with carcinogenesis of colorectal cancer

Authors Zhao K, Jin S, Wei B, Cao S, Xiong Z

Received 14 June 2018

Accepted for publication 6 August 2018

Published 23 November 2018 Volume 2018:10 Pages 6257—6261

DOI https://doi.org/10.2147/CMAR.S177244

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr Antonella D'Anneo


Kexin Zhao,1 Si Jin,2 Bo Wei,3 Shiqiong Cao,1 Zhifan Xiong1

1Division of Gastroenterology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430077, People’s Republic of China; 2Department of Endocrinology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science, Wuhan 430077, People’s Republic of China; 3Department of Oncology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science, Wuhan 430077, People’s Republic of China

Introduction:
Colorectal cancer (CRC) remains a major public health concern worldwide. However, the detailed molecular mechanisms of CRC remain poorly understood.
Methods: In the current study, we evaluated associations of four genetic variants located in the promoter and gene region of long noncoding RNAs metastasis-associated lung adenocarcinoma transcript 1 (lncRNA MALAT1) with CRC susceptibility among a Chinese population with 966 CRC cases and 988 healthy controls, using a two-stage, case–control study design (400 CRC cases and 400 controls in stage 1, and 566 CRC cases and 588 controls in stage 2).
Results: We found that the minor alleles of rs619586 (OR=0.73; 95% CI=0.60–0.88; P=0.001) and rs1194338 (OR=0.80; 95% CI=0.70–0.92; P=0.001) were significantly associated with decreased CRC susceptibility. Compared with those with rs619586 −AA genotype, the risk of CRC was significantly lower in individuals with AG genotype (OR=0.76; 95% CI=0.61–0.95) and GG genotype (OR=0.46; 95% CI=0.23–0.90). Compared with those with rs1194338 −CC genotype, the risk of CRC was significantly lower in individuals with AC genotype (OR=0.79; 95% CI=0.65–0.95) and AA genotype (OR=0.68; 95% CI=0.51–0.89).
Conclusion: Taken together, our findings provided strong evidence for the hypothesis that genetic variants in lncRNA MALAT1 might contribute to the carcinogenesis of CRC.

Keywords: colorectal cancer, genetic, lncRNA, susceptibility, MALAT1

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]