Association of caveolin-1 protein expression with hepatocellular carcinoma: a meta-analysis and literature review
Authors Zhang Y, Fan W, Wu J, Dong J, Cui Z
Received 9 November 2018
Accepted for publication 7 March 2019
Published 31 May 2019 Volume 2019:11 Pages 5113—5122
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Andrew Yee
Peer reviewer comments 2
Editor who approved publication: Dr Kenan Onel
Yan Zhang,1,* Wenjuan Fan,2,* Jiang Wu,1 Jinglong Dong,1 Zhanjun Cui3
1Department of Pathology, Huaihe Hospital, Henan University, Kaifeng 475000, People’s Republic of China; 2Medical Bioengineering Key Laboratory, Luohe Medical College, Luohe 462002, People’s Republic of China; 3School of Basic Medical Sciences, Henan University, Kaifeng 475004, People’s Republic of China
*These authors contributed equally to this work
Background: Aberrant expression of caveolin-1 (CAV-1) is involved in the pathogenesis of hepatocellular carcinoma (HCC); however, the results have been inconsistent due to the small size of sample in the individual study.
Methods: We performed a meta-analysis and evaluated the association of CAV-1 protein overexpression and clinicopathological significance by using Review Manager 5.2. Pooled ORs and HR with corresponding CIs were calculated.
Results: Nine studies were included in the meta-analysis with 810 HCC and 172 cirrhosis patients. CAV-1 protein overexpression was correlated with the risk of cirrhosis; OR was 3.25, p=0.01. Furthermore, the rate of CAV-1 protein overexpression was significantly higher in HCC with cirrhosis than HCC without cirrhosis, suggesting that the CAV-1 protein overexpression likely initiated carcinogenesis in liver with cirrhosis and subsequently contributed to the progression of HCC. In addition, CAV-1 protein overexpression was strongly associated with poor differentiated HCC and invasion; ORs were 2.61 and 2.71, respectively. CAV-1 protein overexpression was strongly correlated with poor overall survival in patients with HCC; HR was 0.4, p=0.03.
Conclusions: In summary, CAV-1 protein overexpression is at risk for liver cirrhosis and HCC derived from cirrhosis, and CAV-1 is also a promising prognostic predictor in HCC.
Keywords: hepatocellular carcinoma, caveolin-1, prognosis, diagnosis, overexpression
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