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Association of caveolin-1 protein expression with hepatocellular carcinoma: a meta-analysis and literature review

Authors Zhang Y, Fan W, Wu J, Dong J, Cui Z

Received 9 November 2018

Accepted for publication 7 March 2019

Published 31 May 2019 Volume 2019:11 Pages 5113—5122

DOI https://doi.org/10.2147/CMAR.S194033

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Andrew Yee

Peer reviewer comments 2

Editor who approved publication: Dr Kenan Onel


Yan Zhang,1,* Wenjuan Fan,2,* Jiang Wu,1 Jinglong Dong,1 Zhanjun Cui3

1Department of Pathology, Huaihe Hospital, Henan University, Kaifeng 475000, People’s Republic of China; 2Medical Bioengineering Key Laboratory, Luohe Medical College, Luohe 462002, People’s Republic of China; 3School of Basic Medical Sciences, Henan University, Kaifeng 475004, People’s Republic of China

*These authors contributed equally to this work

Background: Aberrant expression of caveolin-1 (CAV-1) is involved in the pathogenesis of hepatocellular carcinoma (HCC); however, the results have been inconsistent due to the small size of sample in the individual study.
Methods: We performed a meta-analysis and evaluated the association of CAV-1 protein overexpression and clinicopathological significance by using Review Manager 5.2. Pooled ORs and HR with corresponding CIs were calculated.
Results: Nine studies were included in the meta-analysis with 810 HCC and 172 cirrhosis patients. CAV-1 protein overexpression was correlated with the risk of cirrhosis; OR was 3.25, p=0.01. Furthermore, the rate of CAV-1 protein overexpression was significantly higher in HCC with cirrhosis than HCC without cirrhosis, suggesting that the CAV-1 protein overexpression likely initiated carcinogenesis in liver with cirrhosis and subsequently contributed to the progression of HCC. In addition, CAV-1 protein overexpression was strongly associated with poor differentiated HCC and invasion; ORs were 2.61 and 2.71, respectively. CAV-1 protein overexpression was strongly correlated with poor overall survival in patients with HCC; HR was 0.4, p=0.03.
Conclusions: In summary, CAV-1 protein overexpression is at risk for liver cirrhosis and HCC derived from cirrhosis, and CAV-1 is also a promising prognostic predictor in HCC.

Keywords: hepatocellular carcinoma, caveolin-1, prognosis, diagnosis, overexpression


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