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Association of Cardiovascular Risk Assessment with Early Colorectal Neoplasia Detection in Asymptomatic Population: A Systematic Review and Meta-Analysis

Authors Chen Y, Chen X, Wang X, Liu Z, Zhou H, Xu S

Received 15 May 2020

Accepted for publication 19 July 2020

Published 11 August 2020 Volume 2020:12 Pages 865—873

DOI https://doi.org/10.2147/CLEP.S262939

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Eyal Cohen


Yanwei Chen,1 Xuechen Chen,2 Xi Wang,2 Zhunzhun Liu,2 Haibo Zhou,3 Shu Xu4

1Infection Control Department of Shenzhen Hospital of University of Chinese Academy of Sciences, Shenzhen, People’s Republic of China; 2Medical Faculty Heidelberg, University of Heidelberg, Heidelberg, Germany; 3Institute of Pharmaceutical Analysis, College of Pharmacy, Jinan University, Guangzhou, People’s Republic of China; 4Oncology Department of Shenzhen Hospital of University of Chinese Academy of Sciences, Shenzhen, People’s Republic of China

Correspondence : Shu Xu Email selflearner@126.com

Abstract: Previous studies have shown a strong coexistence of colorectal neoplasia (CRN) and cardiovascular diseases (CVD). This study was aimed to summarize the available evidence on association of CVD risk with early CRN detection in asymptomatic populations. PubMed, Web of Science, and Embase were systematically searched for eligible studies published until Dec 20, 2019. Studies exploring the associations of recommended CVD risk assessment methods (e.g., risk scores, carotid artery plaque, and coronary artery calcium score [CACS]) with risk of CRN were included. Meta-analyses were conducted to determine the overall association of CVD risk with the CRN. A total of 12 studies were finally included. The association of carotid artery plaque with the risk of colorectal adenoma (AD) was weakest (pooled odds ratio [OR)] 1.27, 95% confidence interval [CI), 1.12, 1.45]. Participants with CACS> 100 had about 2-fold increased risk of AD than those with CACS=0. The pooled ORs were 3.36 (95% CI, 2.15, 5.27) and 2.30 (95% CI, 1.69, 3.13) for the risk of advanced colorectal neoplasia (AN) and AD, respectively, in participants with Framingham risk score (FRS)> 20%, when compared to participants at low risk (FRS< 10%). FRS might help identify subgroups at increased risk for AN, but further studies are needed.

Keywords: cardiovascular disease, risk assessment, colorectal neoplasia

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