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Association between lipid accumulation product and diabetic retinopathy based on a community-based survey in Chinese with type 2 diabetes

Authors Wu J, Zhong Y, Yue S, Guan P, Zhang G, Liu L, Chen L

Received 22 November 2018

Accepted for publication 19 February 2019

Published 16 April 2019 Volume 2019:12 Pages 513—518

DOI https://doi.org/10.2147/DMSO.S195578

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Andrew Yee

Peer reviewer comments 2

Editor who approved publication: Dr Juei-Tang Cheng


Jingyang Wu,1 Yifan Zhong,1 Song Yue,1 Peng Guan,2 Guisen Zhang,3 Lei Liu,1 Lei Chen1

1Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, People’s Republic of China; 2Department of Epidemiology, School of Public Health, China Medical University, Shenyang 110122, People’s Republic of China; 3Department of Ophthalmology, Hohhot Chao Ju Eye Hospital, Hohhot 010000, People’s Republic of China

Purpose: Abnormal levels of lipid accumulation product (LAP) have been associated with risk of cardiovascular disease and diabetes. However, it is not clear whether LAP index is associated with diabetic retinopathy (DR). We investigated the association between LAP index and DR in Chinese adults with diabetes.
Patients and methods: We included 427 Chinese patients with type 2 diabetes aged 18-year over who participated in a community-based cross-sectional study in Shenyang. DR was addressed on retinal photographs graded using the modified Airlie House classification. LAP was defined as (waist circumference [cm]–65) × (triglycerides [mmol/L]) in men, and (waist circumference [cm]–58) × (triglycerides [mmol/L]) in women and analyzed continuously (per SD change) and categorically (quartile 1, <30; quartile 2, 30–50; and quartile 3, >50).
Results: Prevalence of DR among the study population was 17.8%. The mean level of LAP was 52.96±44.01. Compared to quartile 1 level, both quartile 2 and 3 levels were associated with DR with multivariable odds ratio (95% CI) of 0.23 (0.12–0.46) and 0.27 (0.14–0.54), respectively. These associations persisted when LAP was analyzed continuously (0.57 [0.35–0.92]).
Conclusion: Higher central lipid accumulation in Chinese diabetics is related to the lower risk of DR, suggesting that LAP may be useful for identifying type 2 diabetes mellitus patients who are at risk for DR.

Keywords: diabetic retinopathy, lipid accumulation product, diabetes


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