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Association Between Glucose Metabolism And Vascular Aging In Chinese Adults: A Cross-Sectional Analysis In The Tianning Cohort Study

Authors Yu J, Sun H, Shang F, Wu H, Shi H, Ren L, He Y, Zhang M, Peng H

Received 18 July 2019

Accepted for publication 28 October 2019

Published 6 November 2019 Volume 2019:14 Pages 1937—1946

DOI https://doi.org/10.2147/CIA.S223690

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr Zhi-Ying Wu


Jia Yu,1,* Hongyan Sun,2,* Fei Shang,2,* Haishu Wu,2 Hongfei Shi,2 Liyun Ren,1 Yan He,1 Mingzhi Zhang,1 Hao Peng1

1Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, People’s Republic of China; 2Center for Disease Prevention and Control of Tianning District, Changzhou, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Hao Peng
Department of Epidemiology, School of Public Health And Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, 199 Renai Road, Industrial Park, Suzhou 215123, People’s Republic of China
Tel +86 512 6588 0078
Fax +86 512 6588 0052
Email penghao@suda.edu.cn

Mingzhi Zhang
Department of Biostatistics, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, 199 Renai Road, Industrial Park, Suzhou 215123, People’s Republic of China
Tel +86 512 6588 0079
Fax +86 512 6588 0052
Email zhangmingzhi@suda.edu.cn

Aim: Fasting glucose has been associated with vascular aging, but the association between HbA1c and vascular aging has been limitedly studied in Chinese and other ethnic populations. We aimed to examine this association in a large sample of Chinese adults.
Methods: In the Tianning Cohort (N=5142), fasting glucose, HbA1c, carotid-femoral pulse wave velocity (cfPWV), and pulse pressure (PP) were measured. Vascular aging was defined as having the highest quartile level of cfPWV or PP. We applied quantile regression models to examine the association between glucose metabolism and vascular aging.
Results: The median cfPWV was significantly increased as increasing quintiles of fasting glucose (β=0.14, P<0.001) and HbA1c (β=0.07, P=0.0056), respectively. Per 1-mmol/L increment of fasting glucose was significantly associated with a higher risk of having vascular aging defined by cfPWV (OR=1.05, P=0.022), PP (OR=1.06, P=0.048), or either (OR=1.08, P=0.002). Similarly, per 1% increment of HbA1c was significantly associated with a higher risk of having vascular aging defined by cfPWV (OR=1.06, P=0.044), PP (OR=1.10, P=0.012), or either (OR=1.12, P=0.042).
Conclusion: Glucose metabolism was significantly and positively associated with vascular aging in Chinese adults, but the causality is uncertain.

Keywords: vascular aging, glucose metabolism, Chinese, fasting glucose

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