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Antibiotic therapy and Clostridium difficile infection – primum non nocere – first do no harm

Authors Crowther GS, Wilcox MH

Received 23 April 2015

Accepted for publication 20 May 2015

Published 15 September 2015 Volume 2015:8 Pages 333—337

DOI https://doi.org/10.2147/IDR.S87224

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Professor Suresh Antony

Grace S Crowther,1 Mark H Wilcox1,2

1Faculty of Medicine and Health, University of Leeds, Leeds, UK; 2Department of Microbiology, Leeds Teaching Hospitals Trust, Leeds, UK

Abstract: Treatment options for Clostridium difficile infection (CDI) remain limited despite this usually nosocomial infection posing an urgent threat to public health. A major paradox of the management of CDI is the use of antimicrobial agents to treat infection, which runs the risk of prolonged gut microbiota perturbation and so recurrence of infection. Here, we explore alternative CDI treatment and prevention options currently available or in development. Notably, strategies that aim to reduce the negative effects of antibiotics on gut microbiota offer the potential to alter current antimicrobial stewardship approaches to preventing CDI.

Keywords: treatment, prevention, CDI, SYN-004, vaccine, beta-lactams

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