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Case report

Noteworthy comment: There are several problems arising from TKIs resistance mechanisms in patients with EGFR-mutant squamous cell carcinoma of the lung. This case report adds to evidence that dual therapy (Osimertinib and Crizotinib) should be useful to EGFR-mutant lung cancers with emergent MET amplification as acquired resistance. This is a very well written case, which would be of interest to many specialties, with a clear discussion and relevant references.

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Differential response to a combination of full-dose osimertinib and crizotinib in a patient with EGFR-mutant non-small cell lung cancer and emergent MET amplification

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