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Aortic stiffness: pathophysiology, clinical implications, and approach to treatment

Authors Sethi S, Rivera O, Oliveros R, Chilton R

Received 20 December 2013

Accepted for publication 11 February 2014

Published 23 May 2014 Volume 2014:7 Pages 29—34

DOI https://doi.org/10.2147/IBPC.S59535

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Salil Sethi, Oscar Rivera, Rene Oliveros, Robert Chilton

University of Texas Health Science Center, San Antonio, TX, USA

Abstract: Aortic stiffness is a hallmark of aging, and classic cardiovascular risk factors play a role in accelerating this process. Current changes in medicine, which focus on preventive care, have led to a growing interest in noninvasive evaluation of aortic stiffness. Aortic stiffness has emerged as a good tool for further risk stratification because it has been linked to increased risk of atherosclerotic heart disease, myocardial infarction, heart failure, and stroke. This has led to the invention and validation of multiple methods to measure aortic stiffness. Pulse wave velocity is emerging as the gold standard for evaluation of aortic stiffness. This review focuses on the pathophysiology involved in aortic stiffness, methods available for evaluation of aortic stiffness, the importance of central pressure as a predictor of future cardiovascular events, and therapies that affect aortic stiffness.

Keywords: aortic stiffness, pulse wave velocity


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