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Antimicrobial performance of mesoporous titania thin films: role of pore size, hydrophobicity, and antibiotic release

Authors Atefyekta S, Ercan B, Karlsson J, Taylor E, Chung S, Webster TJ, Andersson M

Received 28 August 2015

Accepted for publication 30 November 2015

Published 10 March 2016 Volume 2016:11 Pages 977—990

DOI https://doi.org/10.2147/IJN.S95375

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Linfeng Wu

Peer reviewer comments 3

Editor who approved publication: Dr Lei Yang

Saba Atefyekta,1 Batur Ercan,2,3 Johan Karlsson,1 Erik Taylor,2 Stanley Chung,2 Thomas J Webster,1,4 Martin Andersson1

1Department of Chemistry and Chemical Engineering, Chalmers University of Technology, Gothenburg, Sweden; 2Department of Chemical Engineering, Northeastern University, Boston, MA, USA; 3Department of Metallurgical and Materials Engineering, Middle East Technical University, Ankara, Turkey; 4Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, Saudi Arabia

Abstract:
Implant-associated infections are undesirable complications that might arise after implant surgery. If the infection is not prevented, it can lead to tremendous cost, trauma, and even life threatening conditions for the patient. Development of an implant coating loaded with antimicrobial substances would be an effective way to improve the success rate of implants. In this study, the in vitro efficacy of mesoporous titania thin films used as a novel antimicrobial release coating was evaluated. Mesoporous titania thin films with pore diameters of 4, 6, and 7 nm were synthesized using the evaporation-induced self-assembly method. The films were characterized and loaded with antimicrobial agents, including vancomycin, gentamicin, and daptomycin. Staphylococcus aureus and Pseudomonas aeruginosa were used to evaluate their effectiveness toward inhibiting bacterial colonization. Drug loading and delivery were studied using a quartz crystal microbalance with dissipation monitoring, which showed successful loading and release of the antibiotics from the surfaces. Results from counting bacterial colony-forming units showed reduced bacterial adhesion on the drug-loaded films. Interestingly, the presence of the pores alone had a desired effect on bacterial colonization, which can be attributed to the documented nanotopographical effect. In summary, this study provides significant promise for the use of mesoporous titania thin films for reducing implant infections.

Keywords: mesoporous titania, antibacterial, drug delivery, implant coating

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