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Anti-Nociceptive and Anti-Inflammatory Activity of Hygrophila schulli Leaves

Authors Tekulu GH, Desta A, Hiben MG, Araya EM

Received 23 July 2020

Accepted for publication 18 August 2020

Published 4 September 2020 Volume 2020:13 Pages 497—505

DOI https://doi.org/10.2147/JIR.S269717

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Professor Ning Quan


Gebretsadkan Hintsa Tekulu,1 Abrha Desta,1 Mebrahtom Gebrelibanos Hiben,1 Ephrem Mebrahtu Araya2

1Department of Pharmacognosy, School of Pharmacy, College of Health Sciences, Mekelle University, Mekelle, Ethiopia; 2Department of Pharmacy, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia

Correspondence: Gebretsadkan Hintsa Tekulu Tel +251 914277916
Email gere.maysuru@gmail.com

Purpose: The management of pain and inflammation with non-steroidal anti-inflammatory drugs and opioid analgesics are currently encountering severe adverse reactions. To overcome these problems, herbal remedies may offer new alternative medicines. Hygrophila schulli is a medicinal plant traditionally used for the treatment of pain and inflammation-related disorders; yet, these claims are not scientifically validated. Hence, this study was aimed to validate the traditional use of Hygrophila schulli leaves as anti-inflammatory and analgesic remedy.
Methods: In vitro anti-hyaluronidase assay and in vivo carrageenan-induced hind paw oedema model were used to evaluate the anti-inflammatory property of ethanolic leaf extract of Hygrophila schulli. Tail immersion and acetic acid-induced writhing tests were performed to determine the central and peripheral analgesic activity of the leaf extract, respectively.
Results: The ethanolic leaf extract exhibited significant anti-hyaluronidase activity (P< 0.001) and significant inhibition of carrageenan-induced paw oedema (P< 0.05) compared to untreated controls. Similarly, the extract significantly prolonged the reaction time of mice (P< 0.05) for the hot-water stimuli. Furthermore, an oral dose of the extract showed significant inhibition (P< 0.01) of acetic acid-induced abdominal contractions of mice. Besides, the ethanolic leaf extract did not cause any obvious sign of acute toxicity at a single oral dose of 2 g/kg.
Conclusion: The findings of this study may partially support the acclaimed traditional use of Hygrophila schulli leaves for the treatment of pain and inflammatory conditions.

Keywords: pain, inflammation, carrageenan, hyaluronidase, Hygrophila schulli

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