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Anti-angiogenic effects of biotechnological therapies in rheumatic diseases

Authors Cantatore FP, Maruotti N, Corrado A, Ribatti D

Received 10 June 2017

Accepted for publication 3 October 2017

Published 14 December 2017 Volume 2017:11 Pages 123—128


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Doris Benbrook

Francesco Paolo Cantatore,1 Nicola Maruotti,1 Addolorata Corrado,1 Domenico Ribatti2,3

1Rheumatology Clinic, Department of Medical and Surgical Sciences, University of Foggia Medical School, Foggia, 2Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, 3National Cancer Institute “Giovanni Paolo II”, Bari, Italy

Introduction: Angiogenesis plays a key role in the pathogenesis of numerous rheumatic diseases, such as rheumatoid arthritis, psoriatic arthritis, and vasculitides. Therefore, the inhibition of pathological angiogenesis may be considered a useful therapeutical approach in these rheumatic diseases.
Methods: This review article is based on a literature research about the role of biotechnological therapies in angiogenesis inhibition.
Results and conclusions: Several evidences have demonstrated a role for biotechnological therapies in angiogenesis inhibition. Nevertheless, further research and clinical trials are needed to better quantify the real impact of biotechnological therapies on pathological angiogenesis.

abatacept, anakinra, angiogenesis, rituximab, TNF-α, tocilizumab

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