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Anacetrapib as a potential cardioprotective strategy

Authors Di Bartolo BA, Nicholls SJ

Received 15 September 2017

Accepted for publication 4 November 2017

Published 7 December 2017 Volume 2017:11 Pages 3497—3502

DOI https://doi.org/10.2147/DDDT.S114104

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Akshita Wason

Peer reviewer comments 2

Editor who approved publication: Dr Qiongyu Guo

Belinda A Di Bartolo, Stephen J Nicholls

South Australian Health and Medical Research Institute, University of Adelaide, Adelaide, SA, Australia

Abstract: Cholesteryl ester transfer protein (CETP) facilitates movement of esterified cholesterol between high-density lipoproteins (HDLs) and apolipoprotein B-containing lipoproteins. By virtue of their ability to raise HDL cholesterol and lower low-density lipoprotein cholesterol, pharmacological inhibitors of CETP have received considerable attention as potential new agents in cardiovascular prevention. While early studies of CETP inhibitors have demonstrated a lack of clinical efficacy and potential toxicity, development of the potent CETP inhibitor, anacetrapib, has moved forward, with emerging evidence suggesting a role in reducing cardiovascular events. The experience with anacetrapib and its potential for use in clinical practice are reviewed here.

Keywords: anacetrapib, CETP, lipids, atherosclerosis, cardiovascular disease

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