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ALDH1A2 suppresses epithelial ovarian cancer cell proliferation and migration by downregulating STAT3

Authors Wang Y, Shao F, Chen L

Received 8 July 2017

Accepted for publication 17 August 2017

Published 31 January 2018 Volume 2018:11 Pages 599—608

DOI https://doi.org/10.2147/OTT.S145864

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Samir Farghaly


Yichen Wang, Feng Shao, Lu Chen

Department of Gynecologic Oncology, Zhejiang Cancer Hospital, Hangzhou, China

Abstract: Epithelial ovarian cancer is the deadliest gynecological malignancy worldwide. A better understanding of epithelial ovarian cancer pathogenesis and the molecular mechanism underlying its metastasis may increase overall survival rates. Previous studies have indicated that aldehyde dehydrogenase 1 family member A2 (ALDH1A2) is a candidate tumor suppressor in epithelial ovarian cancer. However, the potential role of ALDH1A2 in the molecular mechanisms of epithelial ovarian cancer remains largely unclear. In the present study, we found lower expression of ALDH1A2 in high-grade epithelial ovarian cancer tissues than in low-grade epithelial ovarian cancer tissues. Overexpression of ALDH1A2 decreased the proliferation and migration of epithelial ovarian cancer cell lines, whereas ALDH1A2 knockdown significantly increased cell growth and migration. Moreover, upregulation of ALDH1A2 also reduced the activation of signal transducer and activator of transcription 3 (STAT3). In conclusion, these findings suggest that ALDH1A2 suppresses epithelial ovarian cancer cell proliferation and migration by downregulating STAT3.

Keywords: ALDH1A2, epithelial ovarian cancer cell, STAT3, migration, cell growth

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