Back to Journals » OncoTargets and Therapy » Volume 11

Alcoholic liver disease and risk of cholangiocarcinoma: a systematic review and meta-analysis

Authors Xiong J, Yin Z, Xu W, Shen Z, Li Y, Lu X

Received 18 August 2018

Accepted for publication 19 October 2018

Published 20 November 2018 Volume 2018:11 Pages 8211—8219


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Leo Jen-Liang Su

Jianping Xiong,1,* ZiJun Yin,2,* Weiyu Xu,1,* Zheng Shen,3 Ye Li,1 Xin Lu1

1Department of Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Beijing 100730, China; 2Department of Oncology, The First Affiliated Hospital, Jinan University, Guangzhou 510630, China; 3Department of Orthopaedics, Anhui No. 2 Provincial People’s Hospital, Hefei 230041, China

*These authors contributed equally to this work

Background: With the purpose of elevating the risk of cholangiocarcinoma (CCA), alcoholic liver disease (ALD) was shown. Nonetheless, the findings were controversial. Herein, a meta-analysis and a systematic review were conducted to study the relation as mentioned above.
Methods: This study searched PubMed, EMBASE, and SI Web of Science carefully for the related studies published prior to March 2018, followed by the random-effects model to calculate the values of pooled risk ratio with 95% CIs. In addition, the analyses of sensitivity and subgroup were carried out to further confirm the stability of the outcomes.
Results: Seven articles, consisting of 413,483 healthy controls and 8,962 CCA patients, were included in this meta-analysis. When compared with normal controls, patients with ALD had an enhanced 3.92-fold CCA risk, with studies being heterogeneous (95% CI =1.96–5.07; OR =3.92; I2 =70.2%). However, subgroup analysis showed that ALD had the enhanced risk of intrahepatic cholangiocarcinoma (ICC), instead of extrahepatic cholangiocarcinoma (ECC) (ICC: 95% CI =3.06–5.92, OR =4.49; ECC: 95% CI =0.90–3.35, OR =2.12). Additionally, when the analysis was stratified by the geographic area, positive association was observed only in western countries rather than eastern countries (western nations: 95% CI =3.34–6.96, OR =5.15; eastern nations: 95% CI =0.38–3.91, OR =2.14). And no essential bias was published.
Conclusion: ALD was greatly associated with the enhanced risk of CCA by 3.92-fold, especially in the ICC.

Keywords: alcoholic liver disease, cholangiocarcinoma, biliary tract neoplasms, meta-analysis

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]