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Advances on Graphene-Based Nanomaterials and Mesenchymal Stem Cell-Derived Exosomes Applied in Cutaneous Wound Healing

Authors Zhao M, Shi J, Cai W, Liu K, Shen K, Li Z, Wang Y, Hu D

Received 7 January 2021

Accepted for publication 27 February 2021

Published 6 April 2021 Volume 2021:16 Pages 2647—2665

DOI https://doi.org/10.2147/IJN.S300326

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Linlin Sun


Ming Zhao, Jihong Shi, Weixia Cai, Kaituo Liu, Kuo Shen, Zichao Li, Yunchuan Wang, Dahai Hu

Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shannxi, 710032, People’s Republic of China

Correspondence: Yunchuan Wang; Dahai Hu
Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shannxi, 710032, People’s Republic of China
Tel +86 29-84775293
; +86 29-84775298
Email [email protected]; [email protected]

Abstract: Graphene is a new type of carbon nanomaterial discovered after fullerene and carbon nanotube. Due to the excellent biological properties such as biocompatibility, cell proliferation stimulating, and antibacterial properties, graphene and its derivatives have become emerging candidates for the development of novel cutaneous wound dressings and composite scaffolds. On the other hand, pre-clinical research on exosomes derived from mesenchymal stem cells (MSC-Exos) has been intensified for cell-free treatment in wound healing and cutaneous regeneration, via ameliorating the damaged microenvironment of the wound site. Here, we provide a comprehensive understanding of the latest studies and observations on the various effects of graphene-based nanomaterials (GBNs) and MSC-Exos during the cutaneous wound repair process, as well as the putative mechanisms thereof. In addition, we propose the possible forward directions of GBNs and MSC-Exos applications, expecting to promote the clinical transformation.

Keywords: graphene, carbon nanomaterials, mesenchymal stem cells, exosomes, wound healing

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