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Adjunctive therapy in Parkinson's disease: the role of rasagiline

Authors Gaines, Hinson V

Received 21 February 2012

Accepted for publication 10 April 2012

Published 2 July 2012 Volume 2012:8 Pages 285—294


Review by Single anonymous peer review

Peer reviewer comments 2

Kathryn D Gaines,1 Vanessa K Hinson2

1Department of Neurology, Aurora Advanced Healthcare, Milwaukee, WI, 2Department of Neurosciences, Movement Disorders Program, Medical University of South Carolina, Charleston, SC, USA

Abstract: Parkinson's disease is the second most common neurodegenerative disorder, currently affecting 1.5 million people in the US. In this review, we describe the diagnostic and pathological features of Parkinson's disease, as well as its clinical course. We then review pharmacologic treatments for the disease, with a particular focus on therapies adjunctive to levodopa and specifically the role of rasagiline. We review the four pivotal rasagiline trials, and discuss rasagiline and its use as adjunctive therapy for Parkinson's disease. Finally, we discuss potential side effects, drug interactions, and other practical aspects concerning the use of rasagiline in Parkinson's disease.

Keywords: Parkinson's disease, treatment, rasagiline, clinical trials

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