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Abnormal microRNA expression in the course of hematological malignancies

Authors Szymczyk A, Macheta A, Podhorecka M

Received 17 May 2018

Accepted for publication 4 July 2018

Published 8 October 2018 Volume 2018:10 Pages 4267—4277

DOI https://doi.org/10.2147/CMAR.S174476

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 3

Editor who approved publication: Dr Kenan Onel


Agnieszka Szymczyk,1 Arkadiusz Macheta,2 Monika Podhorecka2

1Independent Clinical Transplantology Unit, Medical University of Lublin, Lublin, Poland; 2Department of Haematooncology and Bone Marrow Transplantation, Medical University of Lublin, Lublin, Poland

Abstract: Research on the carcinogenesis process is currently focused primarily on understanding its genetic basis and molecular abnormalities that may be predictive factors and therapeutic targets. It was clearly confirmed recently that microRNAs are involved in the mechanisms of leukocyte development, differentiation, and apoptosis, as well as in the pathogenesis of proliferative diseases of the hematopoietic system. Currently, research strategies allow determination of the deregulation of microRNA profiles in relation to other cytogenetic aberrations, as well as prognostic factors and primary end points. The problem of the possibility of their use as therapeutic targets is also increasingly discussed. In this article, we analyze literature data on abnormalities in microRNA expression in proliferative diseases of the hematopoietic system in the context of classic cytogenetic and molecular aberrations.

Keywords: hematological malignancies, microRNA, cytogenetic abnormalities

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