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A Study on the Psychological Factors Affecting the Quality of Life Among Ovarian Cancer Patients in China

Authors Gu ZH, Qiu T, Yang SH, Tian FQ, Wu H

Received 25 November 2019

Accepted for publication 22 January 2020

Published 7 February 2020 Volume 2020:12 Pages 905—912

DOI https://doi.org/10.2147/CMAR.S239975

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Eileen O'Reilly


Zhi-Hui Gu, Tian Qiu, Shi-Han Yang, Fang-Qiong Tian, Hui Wu

Department of Social Medicine, School of Public Health, China Medical University, Shenyang, People’s Republic of China

Correspondence: Hui Wu
Department of Social Medicine, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang 110122, People’s Republic of China
Email hwu@cmu.edu.cn

Purpose: We aim to test whether resilience mediates the association of fear of progression (FoP) with quality of life (QoL) among ovarian cancer patients in China.
Methods: We collected 230 questionnaires from the First Affiliated Hospital of China Medical University in Liaoning Province, and 209 completed the questionnaire survey. The survey instrument consisted of four questionnaires: a sociodemographic and clinical characteristics questionnaire, the Functional Assessment of Cancer Therapy general instrument, the Fear of Progression Questionnaire-Short Form and the Connor-Davidson Resilience Scale. Hierarchical regression analysis was used to examine the relationship among FoP, resilience, and QoL, including physical well-being, social well-being, emotional well-being, and functional well-being. We used asymptotic and resampling strategies to examine the indirect effect of resilience.
Results: FoP was negatively associated with resilience (r=− 0.543, P< 0.01) and QoL (physical well-being: r=− 0.537, P< 0.01; social well-being: r=− 0.426, P< 0.01; emotional well-being: r=− 0.487, P< 0.01; functional well-being: r=− 0.529, P< 0.01). Resilience was positively related with QoL (physical well-being: r=0.449, P< 0.01; social well-being: r=0.548, P< 0.01; emotional well-being: r=0.430, P< 0.01; functional well-being: r=0.655, P< 0.01). Resilience partly mediated the association between FoP and physical well-being (a×b=− 0.05, BCa 95% CI: − 0.09, − 0.02), social well-being (a×b=− 0.21, BCa 95% CI: − 0.29, − 0.14), emotional well-being (a×b=− 0.05, BCa 95% CI: − 0.08, − 0.02), and functional well-being (a×b=− 0.24, BCa 95% CI: − 0.32, − 0.17). The proportion of the mediating effect accounted for by resilience were 22.57%, 57.22%, 26.02%, 53.42% for physical well-being, social well-being, emotional well-being and functional well-being, respectively.
Conclusion: The study showed that resilience could mediate the association between fear of progression and quality of life. It suggests that resilience might provide a potential target for intervention in quality of life with ovarian cancer.

Keywords: mediating role, fear of progression, quality of life, resilience, ovarian cancer patients

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