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A Study on the Correlation Between MDR1 Polymorphism and Clopidogrel Resistance in Hui Patients Treated with Percutaneous Coronary Intervention

Authors Chen F, Zhang J, Bian CX, Zhang J, Xin XB, Pan YY, Zhang X

Received 25 November 2020

Accepted for publication 14 January 2021

Published 25 February 2021 Volume 2021:14 Pages 665—671


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Scott Fraser

Fang Chen,1 Jing Zhang,2 Cheng-Xue Bian,2 Jian Zhang,3 Xiang-Bin Xin,2 Yang-Yang Pan,2 Xuan Zhang2

1Department of Cardiology, Yinchuan First People’s Hospital, Yinchuan, People’s Republic of China; 2Department of Cardiology, Ningxia Medical University, Yinchuan, People’s Republic of China; 3Department of Clinical Laboratory, Yinchuan First People’s Hospital, Yinchuan, People’s Republic of China

Correspondence: Fang Chen
Department of Cardiology, Yinchuan First People’s Hospital, No. 2 of Liqun West Street, Xingqing District, Yinchuan, 750000, People’s Republic of China
Tel +86 0951-6997179
Fax +86 0951-6192355
Email [email protected]

Objective: This study assesses the correlation between MDR1 gene polymorphism and clopidogrel resistance (CR) in Hui patients with coronary heart disease (CHD) who were treated with percutaneous coronary intervention (PCI).
Methods: The study includes 204 Ningxia Hui patients with CHD who were treated with PCI. These patients were divided into two groups: those who with CR and others were non-clopidogrel resistant (NCR), according to the results of the patients’ platelet aggregation rate, which was tested by adenosine diphosphate-induced turbidimetry on the second postoperative day. C3435T and C1236T genotypes and alleles were tested by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
Results: The CR rate was 24.0%, and there were 3 genotypes of C3435T and C1236T. For C3435T, the distribution frequency of the 3435TT genotype and T allele was significantly higher in the CR group than in the NCR group. For C1236T, no significant difference was found between the two groups.
Conclusion: Hui patients who had CHD were treated with PCI. CR was most likely to occur in those who had the T allele of MDR1 in gene C3435T.

Keywords: coronary heart disease, MDR1 gene, clopidogrel resistance, gene polymorphism, platelet aggregation rate

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